Molecular and Cellular Aspects of the Drug Addictions by Avram Goldstein

Molecular and Cellular Aspects of the Drug Addictions by Avram Goldstein

In 1970 I gave up the chairmanship of the Department of Pharmacology at Stanford University Schoel of Medicine to devote full time to basic and clinical research on problems of drug addiction. In 1971 I developed the method of radioligand binding that led to the important characterization of opioid receptors in several laboratories. The extraordinary specificity of these receptors for morphine and related opiates suggested the likelihood that there were naturally occurring morphine-like molecules in the brain and other tissues. The systematic search for these molecules culminated in 1979 in the discovery, by my group, ofthe dynorphin peptides-one of the three families of opioid peptides, the first of which (the enkephalin family) had been discovered in Aberdeen, Scotland, in 1975. I also became involved in clinical research on the pharmacologic treatment of heroin addicts, for which I established the first large methadone mainte- nance treatment program in California. My basic and clinical research experience convinced me that an institution encompassing laboratory research, studies on normal human volunteers, and treatment research, under a single roof, could expedite progress in understanding the drug addictions. That concept was transformed into reality by the founding, in 1974, of the Addiction Research Foundation of Palo Alto, California. The funds for construction of a laboratory were provided by a generous grant from the Drug Abuse Council (a consortium of several foundations), the president of which was Thomas L. Bryant.

Avram Goldstein, M.D. is Emeritus Professor of Pharmacology, Stanford University. He is the author of Principles of Drug Action, is a member of the National Academy of Sciences and the American Academy of Arts and Sciences, and is the recipient of many awards including the Franklin Medal, the Nathan
B. Eddy Award, and the Sollman Award.

SKU	Unavailable
ISBN 13	9781461388197
ISBN 10	1461388198
Title	Molecular and Cellular Aspects of the Drug Addictions
Author	Avram Goldstein
Condition	Unavailable
Binding Type	Paperback
Publisher	Springer-Verlag New York Inc.
Year published	2011-10-18
Number of pages	238
Cover note	Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
Note	Unavailable