{"title":"Advances In Neurochemistry","description":"\u003cp\u003eDelve into the complexities of the brain with the 'Advances in Neurochemistry' series. Explore cutting-edge research and breakthroughs in understanding the chemical processes of the nervous system.\u003c\/p\u003e","products":[{"product_id":"myelin-book-pierre-morell-9781461575160","title":"Myelin","description":"The division of the mature mammalian brain and spinal cord into regions of \"white\" matter and \"gray\" matter is observable upon the most cursory inspection. Microscopic examination indicates that the \"white\" matter regions are characterized by a multilamellar sheath (myelin) which sur­ rounds the axons. A morphologically similar myelin imparts the white color to tracts of the peripheral nervous system, although, as is empha­ sized throughout the book, there are very significant morphological and chemical differences between central and peripheral myelin. The rapid postnatal accumulation of myelin is temporally associated with increasing functional capacity and presumably indicates some important role related to neuronal activity. The ability of myelinated axons to conduct electrical impulses much more rapidly and with much lower use of energy, relative to unmyelinated axons, is now generally accepted. As is evident from the above capsule description, a considerable body of information concerning myelin is available. However, as in other areas of research the unknown expands before us more rapidly than we are able to add to our core of knowledge. This is a corollary of the axiom that a good experiment raises more questions than it answers. Among the areas currendy under investigation in many laboratories are the following: interaction of myelin-forming cells with neurons, assembly and metabo­ lism of myelin, molecular architecture of myelin, and the details of the functional role of myelin.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ GARDNERS","offer_id":49735174553873,"sku":"NGR9781461575160","price":0.0,"currency_code":"GBP","in_stock":false},{"title":"GB \/ NEW \/ INGRAM","offer_id":52663753343249,"sku":"NLS9781461575160","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/1461575168.jpg?v=1750714937"},{"product_id":"neurochemical-correlates-of-cerebral-ischemia-book-nicolas-g-bazan-9781461364580","title":"Neurochemical Correlates of Cerebral Ischemia","description":"In this timely volume, eminent researchers provide detailed  coverage of the relevant function of neurochemical correlates to  cerebral  ischemia as well as their pathophysiological significance.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52089122750737,"sku":"NLS9781461364580","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461364580.jpg?v=1756905851"},{"product_id":"oligodendroglia-book-william-norton-9781475760682","title":"Oligodendroglia","description":"This series has addressed a constituency of scientists possessing biochemical background with the goal of providing them with specialized reviews of neu- robiological interest. Since its initiation, neurochemistry and neuroscience have come of age, and the editors initiate with this volume the concept of a central theme. It is planned that each subsequent volume will also be topical. We note with sadness the passing of Dr. Henry Mahler who served as an advisory editor since the initiation of this series. He played a major role in building the bridge between biochemistry and neurochemistry and will be missed. Weare pleased to welcome two new editors, Drs. William Norton and Bruce McEwen. B. W. Agranoff M. H. Aprison vii FOREWORD Oligodendroglia constitute one of the three principal cell types of the central nervous system. These cells, together with their elaborated membranes, account for at least 25 percent of the dry mass of an adult rat brain and an even greater percentage of the central nervous system of larger animals.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52407755997457,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52407756587281,"sku":"NLS9781475760682","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781475760682.jpg?v=1758772959"},{"product_id":"axonal-transport-in-neuronal-growth-and-regeneration-book-john-elam-9781468411997","title":"Axonal Transport in Neuronal Growth and Regeneration","description":"Over the past several years, the pace of research on the control of axonal growth has increased at a remarkable rate, and this activity is reflected in a growing literature dealing with various aspects of axonal growth and regener- ation. It appears timely to review the role played by axonal transport in the intrinsic responses of neurons in the growth and regrowth processes. Through the cooperation of the senior editors of this series, we have been given the opportunity to bring such a focus to the current volume. We wish to acknowledge that the contributing authors attended a confer- ence on The Role of Axonal Transport in Neuronal Growth and Regenera- tion held in Tallahassee, Florida in March, 1983, sponsored by the Psycho- biology Research Center of the Florida State University. It is our hope that many of the perceptions and insights expressed in these chapters resulted from our interactions.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52662336913681,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52662337700113,"sku":"NLS9781468411997","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781468411997.jpg?v=1762269272"},{"product_id":"mouse-models-in-the-study-of-genetic-neurological-disorders-book-brian-popko-9780306459658","title":"Mouse Models in the Study of Genetic Neurological Disorders","description":"The number of mouse models that are available for the study of human genetic neurological disorders is large and growing rapidly. Therefore, it was difficult to select the models that were reviewed in this volume. Clearly, there are important models that are not discussed, and perhaps a volume twice this size would have been more appropriate. Moreover, the pace at which new models are being developed and analyzed is rapid. As this volume goes to press, I am sure that additional mouse genes responsible for naturally occurring neurological disorders are being discovered and that many new transgenic and mutant mouse strains are being developed. Therefore, this volume should not be viewed as a comprehensive compendium, but rather as an update of work in progress. It is exhilarating to witness the fast pace at which these models are being established as important tools in the study of basic neuroscience and neurological disorders. It will be even more exciting to see their utilization in the development and testing of therapeutic interventions for these diseases. I would like to thank each of the authors who have contributed to this volume for their time and their expertise. I would also like to thank Drs. Timothy Coetzee and Joshua Corbin for their advice in the selection of the topics covered. I am deeply indebted to Dr. Kunihiko Suzuki, who first approached me with the idea for this volume, for his guidance throughout its preparation.","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52663825563921,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52663826350353,"sku":"NLS9780306459658","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780306459658.jpg?v=1762273015"},{"product_id":"magnetic-resonance-spectroscopy-and-imaging-in-neurochemistry-book-h-s-bachelard-9780306455209","title":"Magnetic Resonance Spectroscopy and Imaging in Neurochemistry","description":"The Advances in Neurochemistry series was initiated for a readership of neuroscientists with a background in biochemistry. True to this concept, the present volume brings together various applications of magnetic resonance technology to advance our knowledge of how the nervous system functions. Whether at the cellular, tissue slice, or intact organism level. magnetic resonance techniques are by their nature noninvasive, and thus provide a window through which biochemical reactions can be viewed without grinding, binding, or other- wise perturbing ongoing physiological processes. As technological improve- ments in methodology, such as higher and more uniform magnetic fields, novel paradigms for data analysis, etc., are made, we find increased sensitivity and improved temporal and spatial resolution for functional imaging techniques on the one hand, and better separation of signals that identify chemical properties in spectral shift studies, on the other. It is upon knowledge such as is described in the twelve chapters that follow, that further advances in scientific discovery and the biomedical applications of tomorrow will be based. We are grateful to Dr. Bachelard, the Volume Editor, and to the authors of the individual chapters for their efforts. We also note that with this volume Dr. Morris Aprison, a co-founder of the Advances in Neurochemistry series has stepped down and acknowledge with thanks his major role in its inception. In addition, we thank our past and present Advisory Editors. Bernard W. Agranoff Kunihiko Suzuki Series Editors ix CONTENTS LIST OF SYMBOLS AND GLOSARY . . . . . . . . . . . . . . . . . . . . . . . . . . . XI INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52664121164049,"sku":"NLS9780306455209","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52734878581009,"sku":"NIN9780306455209","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9780306455209.jpg?v=1762273790"},{"product_id":"magnetic-resonance-spectroscopy-and-imaging-in-neurochemistry-book-herman-bachelard-9781461376880","title":"Magnetic Resonance Spectroscopy and Imaging in Neurochemistry","description":"The Advances in Neurochemistry series was initiated for a readership of neuroscientists with a background in biochemistry. True to this concept, the present volume brings together various applications of magnetic resonance technology to advance our knowledge of how the nervous system functions. Whether at the cellular, tissue slice, or intact organism level. magnetic resonance techniques are by their nature noninvasive, and thus provide a window through which biochemical reactions can be viewed without grinding, binding, or other- wise perturbing ongoing physiological processes. As technological improve- ments in methodology, such as higher and more uniform magnetic fields, novel paradigms for data analysis, etc., are made, we find increased sensitivity and improved temporal and spatial resolution for functional imaging techniques on the one hand, and better separation of signals that identify chemical properties in spectral shift studies, on the other. It is upon knowledge such as is described in the twelve chapters that follow, that further advances in scientific discovery and the biomedical applications of tomorrow will be based. We are grateful to Dr. Bachelard, the Volume Editor, and to the authors of the individual chapters for their efforts. We also note that with this volume Dr. Morris Aprison, a co-founder of the Advances in Neurochemistry series has stepped down and acknowledge with thanks his major role in its inception. In addition, we thank our past and present Advisory Editors. Bernard W. Agranoff Kunihiko Suzuki Series Editors ix CONTENTS LIST OF SYMBOLS AND GLOSARY . . . . . . . . . . . . . . . . . . . . . . . . . . . XI INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .","brand":"WoB","offers":[{"title":"- \/ - \/ INTERNAL","offer_id":52674022277393,"sku":null,"price":0.0,"currency_code":"GBP","in_stock":true},{"title":"GB \/ NEW \/ INGRAM","offer_id":52674023194897,"sku":"NLS9781461376880","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461376880.jpg?v=1762298548"},{"product_id":"advances-in-neurochemistry-book-b-w-agranoff-9781468475432","title":"Advances in Neurochemistry","description":"The original premise of the Editors in initiating this series was that there existed a readership ofneurochemists with considerable biochemical back- ground who would make use of a series dedicated to both new develop- ments and specialized reviews in neurochemistry. Having selected our authors, we have offered them virtually complete freedom to reflect and speculate in a field in which they have achieved prominence. The response to the first two volumes has been rewarding. The present one continues in this tradition. While we have not attempted to publish specialized volumes, the present volume contains two somewhat related chapters (Chapters 4 and 5, on the role of amino acid neurotransmitters). The first three chapters examine three diverse approaches, each of current interest, in neurochemi- cal approaches to the molecular bases of neuronal and glial structure. B. W. Agranoff M. H. Aprison vii CONTENTS CHAPTER 1 2',3'-CYCUC NUCLEOTIDE 3'-PHOSPHODIESTERASE NEIL RAYMOND SIMS AND PATRICK ROBERT CARNEGIE 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Assay of CNPase . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. Need for Activation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 2. Comparison of Assays . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 3. Association of CNPase with Myelin . . . . . . . . . . . . . . . . . . . . . . . 7 3. 1. Historical. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3. 2. Subcellular Fractionation. . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. 3. Development. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. 4. Mutant Mice . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 3. 5. Use as a Myelin Marker . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 3. 6. Myelin-Related Fractions and Peripheral Nerve Myelin. 11 4. CNPase in Nonmyelin Fractions. . . . . . . . . . . . . . . . . . . . . . . . . . 13 5. Activation and Isolation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 5. 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 5. 2. Activation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 5. 3. Solubilization and Fractionation. . . . . . . . . . . . . . . . . . . . . . 15 6. Properties. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 6. 1. Substrate Specificity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52674884108561,"sku":"NLS9781468475432","price":0.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781468475432.jpg?v=1762300629"},{"product_id":"mouse-models-in-the-study-of-genetic-neurological-disorders-book-brian-popko-9781461372172","title":"Mouse Models in the Study of Genetic Neurological Disorders","description":"The number of mouse models that are available for the study of human genetic neurological disorders is large and growing rapidly. Therefore, it was difficult to select the models that were reviewed in this volume. Clearly, there are important models that are not discussed, and perhaps a volume twice this size would have been more appropriate. Moreover, the pace at which new models are being developed and analyzed is rapid. 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I am deeply indebted to Dr. Kunihiko Suzuki, who first approached me with the idea for this volume, for his guidance throughout its preparation.","brand":"WoB","offers":[{"title":"GB \/ NEW \/ INGRAM","offer_id":52676394483985,"sku":"NLS9781461372172","price":0.0,"currency_code":"GBP","in_stock":true},{"title":"US \/ NEW \/ INGRAM","offer_id":52953460605201,"sku":"NIN9781461372172","price":0.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/9781461372172.jpg?v=1762304157"},{"product_id":"neurochemical-correlates-of-cerebral-ischemia-book-nicolas-g-bazan-9780306439445","title":"Neurochemical Correlates of Cerebral Ischemia","description":"Summarizes the current knowledge on neurochemical correlates of what most of us know as stroke, emphasizing their relevance to function and their pathophysiological significance. 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