Evolutionary conserved features of FG repeats that allow the formation of hydrogel-based perme-ability barriers with NPC-like properties by Hermann Broder Schmidt

Evolutionary conserved features of FG repeats that allow the formation of hydrogel-based perme-ability barriers with NPC-like properties by Hermann Broder Schmidt

Non-globular FG domains constitute the permeability barrier of nuclear pore complexes (NPCs), which control all macromolecular exchange between nucleus and cytoplasm. Whilst objects smaller than 30kDa can passively diffuse across this barrier, larger molecules need to be chaperoned by nuclear transport receptors (NTRs). However, the modus operandi and, inextricably linked, the exact physical nature of the NPC permeability barrier are still controversially discussed. Whereas so far, most studies exclusively focused on yeast or vertebrate FG domains, the ability of FG domains from different species to form selective barriers was explored here. Interestingly, all studied species contain 'cohesive' FG domains that interact with each other to form a characteristic (hydrogel) phase mimicking the permeability properties of NPCs.

SKU	Non disponible
ISBN 13	9783954044917
ISBN 10	3954044919
Titre	Evolutionary conserved features of FG repeats that allow the formation of hydrogel-based perme-ability barriers with NPC-like properties
Auteur	Hermann Broder Schmidt
État	Non disponible
Type de reliure	Paperback
Éditeur	Cuvillier
Année de publication	2013-08-23
Nombre de pages	172
Note de couverture	La photo du livre est présentée à titre d'illustration uniquement. La reliure, la couverture ou l'édition réelle peuvent varier.
Note	Non disponible