{"product_id":"my-brother-s-a-world-class-pain-book-michael-gordon-9780962770128","title":"My Brother's a World-Class Pain","description":"Since human prolactin was isolated and characterized 13 years ago, the study of the control of prolactin secretion has been intensive. Hyperprolactinaemia is the most commonly identifiable hypothal- amic pituitary disorder1,2. The dominant inhibitory nature of hypo- thalamic control of prolactin secretion may be the reason that hyperprolactinaemia is such a common condition. During the PClst decade two separate therapeutic approaches to the management of hyperprolactinaemia have been introduced: transsphenoidal selec- tive pituitary microsurgery and medical therapy to suppress prolactin secretion with orally active long-acting dopamine agonist drugs. Small prolactin-secreting tumours are treated extremely satisfactorily both with medical and with surgical therapy, both in terms of lower- ing serum prolactin levels to normal and in restoring gonadal func- tion. However, for the larger tumours, either where the tumour is invasive or the pretreatment serum prolactin level is greater than 1 250ngml- the results of surgery are poor in terms of restoring to normal circulating prolactin levels and gonadal functionJ-s. We now discuss the medical management of hyperprolactinaemia, potential problems during pregnancy and the management of large prolactin- secreting pituitary tumours.","brand":"WoB","offers":[{"title":"US \/ GOOD \/ SBYB","offer_id":49949582426385,"sku":"CIN0962770124G","price":18.88,"currency_code":"USD","in_stock":false},{"title":"GB \/ VERY_GOOD \/ INTERNAL","offer_id":50128134963473,"sku":"GOR006400138","price":28.99,"currency_code":"USD","in_stock":true},{"title":"GB \/ GOOD \/ INTERNAL","offer_id":50259554074897,"sku":"GOR003611908","price":17.99,"currency_code":"USD","in_stock":false},{"title":"US \/ WELL_READ \/ SBYB","offer_id":51704783995153,"sku":"CIN0962770124A","price":31.15,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0784\/4072\/6801\/files\/0962770124.gif?v=1751013569","url":"https:\/\/www.worldofbooks.com\/products\/my-brother-s-a-world-class-pain-book-michael-gordon-9780962770128","provider":"World of Books ","version":"1.0","type":"link"}