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Primary Aldosteronism Per Hellman

Primary Aldosteronism By Per Hellman

Primary Aldosteronism by Per Hellman

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Summary

Primary Aldosteronism (PA) is a disease caused by the overproduction of aldosterone hormone from the adrenal glands. PA causes hypertension and the majority with this disease are undiagnosed for PA. In 2011, a breakthrough in the genetic derangements came, identifying a mutated potassium channel gene - KCNJ5 - in about 40% of PA with adenoma.

Primary Aldosteronism Summary

Primary Aldosteronism: Molecular Genetics, Endocrinology, and Translational Medicine by Per Hellman

Primary Aldosteronism (PA) is a disease caused by the overproduction of aldosterone hormone from the adrenal glands. PA causes hypertension and the majority with this disease are undiagnosed for PA. There are new insights into this matter by using biochemistry as well as advanced radiology. In 2011, a breakthrough in the genetic derangements came, identifying a mutated potassium channel gene - KCNJ5 - in about 40% of PA with adenoma. Chapters in this book include a history of the disorder, epidemiology, genetics derangements, the KCNJ5 mutations and phenotype and more.

Table of Contents

Introduction.- Primary Aldosteronism: Molecular Mechanisms and Diagnosis.- Epidemiology and need for screening.- Low renin hypertension.- Molecular derangements in sporadic primary aldosteronism.- From genetic abnormalities to pathophysiological mechanisms.- Familial hyperaldosteronism type I.- Familial hyperaldosteronism type II.- Familial hyperaldosteronism type III.- The Aldosterone-renin ratio - role and problems.- Confirmatory testing for Primary Aldosteronism.- Radiological imaging of adrenocortical tumors.- Aldosterone and cardiovascular disease.- Quality of life aspects of primary aldosteronism.- Medical treatment of primary aldosteronism.- Surgical treatment of primary aldosteronism.- Index.

Additional information

NLS9781493946228
9781493946228
1493946226
Primary Aldosteronism: Molecular Genetics, Endocrinology, and Translational Medicine by Per Hellman
Per Hellman
New
Paperback
Springer-Verlag New York Inc.
2016-08-23
233
N/A
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
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