Preface to the 2nd Edition ix
Chapter 1. The Scope and Basic Premises of Population Genetics 1-1
Basic Premises of Population Genetics 1-1
Population Genomics1-12
Section 1: Population Structure and History
Chapter 2. Modeling Evolution and the Hardy-Weinberg Law 2-1
How to Model Microevolution 2-1
The Hardy-Weinberg Model 2-4
Hardy-Weinberg for Two Loci2-19
Chapter 3. Systems of Mating 3-1
Inbreeding 3-1
Assortative Mating3-25
Disassortative Mating3-45
Chapter 4. Genetic Drift 4-1
Basic Evolutionary Properties of Genetic Drift 4-2
Founder and Bottleneck Effects 4-7
Genetic Drift and Disequilibrium4-11
Genetic Drfit, Disequilibrium, and System of Mating4-13
Effective Population Size4-18
Chapter 5. Genetic Drift in Large Populations and Coalescence 5-1
Newly Arisen Mutations 5-1
Neutral Alleles 5-3
The Coalescent5-22
Chapter 6. Gene Flow and Population Subdivision 6-1
Gene Flow Between Two Local Populations 6-1
The Balance of Gene Flow and Drift 6-6
An Example of the Balance of Drift and Gene Flow6-27
Factors Influencing The Amount and Patter of Gene Flow6-42
Total Effective Population Size in Subdivided Populations6-62
Multiple Modes of Inheritance and Population Structure6-71
Admixture6-76
Identifying Subpopulations and Population Structure6-81
A Final Warning6-96
Chapter 7. Population History 7-1
Inferring Historical Effective Population Sizes 7-6
Inferring Historical Gene Flow Patterns and Admixture 7-11
Using Haplotype Trees to Study Population History 7-19
Model Based Approaches to Phylogeographic Analysis 7-56
Direct Studies Over Space and Past Times 7-70
Historical Population Genetics and Macroevolution 7-75
Section 2: Genotype and Phenotype
Chapter 8. Basic Quantitative Genetic Definitions and Theory 8-1
Simple Mendelian Phenotypes 8-2
Nature Versus Nurture? 8-7
The Fisherian Model of Quantitative Genetics8-13
Chapter 9. Quantitative Genetics: Unmeasured Genotypes 9-1
Correlation Between Relatives 9-2
The Distinction Between Heritability and Inheritance9-17
Response to Selection9-19
The Problem of Between-Population Differences in Mean
Phenotype 9-21
Controlled Crosses for the Analysis of Between Population
Differences 9-30
The Balance Between Mutation, Drift, and Gene Flow Upon
Phenotypic Variance 9-36
Chapter 10. Quantitative Genetics: Measured Genotypes 10-1
Marker Association Studies 10-5
Candidate Loci10-35
Candidate Loci and Genetic Architecture10-51
Section 3: Natural Selection and Adaptation
Chapter 11. Natural Selection 11-1
The Fundamental Equation of Natural Selection: Measured
Genotypes 11-4
Sickle-Cell Anemia as an Example of Natural Selection 11-10
Adaptation as a Polygenic Process 11-24
The Fundamental Theorem of Natural Selection: Unmeasured
Genotypes 11-29
Some Implications of the Fundamental Equations of Natural
Selection 11-33
The Course of Adaptation and Natural Selection 11-47
Chapter 12. Interactions of Natural Selection with Other Evolutionary Forces
and the Detection of Natural Selection 12-1
The Interaction of Natural Selection with Mutation 12-3
The Interaction of Natural Selection with Mutation and System of
Mating 12-8
The Interaction of Natural Selection with Gene Flow 12-12
The Interaction of Natural Selection with Genetic Drift 12-21
The Interactions of Natural Selection, Genetic Drift, and
Gene Flow 12-28
The Interactions of Natural Selection, Genetic Drift, and Mutation 12-45
The Interactions of Natural Selection, Genetic Drift, Mutation, and
Recombination 12-65
Candidate Loci 12-71
Quantitative Genetic Approaches to Detecting Selection 12-75
The Neutralist/Selectionist Debate 12-80
Chapter 13. Units and Targets of Selection 13-1
The Unit of Selection 13-4
Targets of Selection Below the Level of the Individual 13-18
Targets of Selection Above the Level of the Individual 13-51
Chapter 14. Selection in Heterogeneous Environments 14-1
Coarse-Grained Spatial Heterogeneity 14-4
Coarse-Grained Temporal Heterogeneity 14-34
Fine-Grained Heterogeneity 14-56
Coevolution 14-74
Chapter 15. Selection in Age-Structured Populations 15-1
Life History and Fitness 15-3
The Evolution of Senescence 15-13
Abnormal Abdomen: An Example of Selection in an
Age-Structured Population 15-24
Overview 15-63
Appendices
Appendix 1. Genetic Survey Techniques A1-1
Appendix 2. Probability and Statistics A2-1
References R-1
Index