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Antiepileptic Drug Discovery By Alan Talevi

Antiepileptic Drug Discovery by Alan Talevi

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Antiepileptic Drug Discovery Summary

Antiepileptic Drug Discovery: Novel Approaches by Alan Talevi

This thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches for the identification of new drug candidates, and therapeutic strategies to overcome refractory epilepsy. The last section illustrates the potential benefits that network pharmacology and rational drug repurposing could bring to the antiepileptic drug discovery community. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of detailed description and implementation advice to ensure results in the laboratory.
Authoritative and practical, Antiepileptic Drug Discovery: Novel Approaches aims to provide medicinal chemists, pharmacologists, and other researchers with the tools need to further explore the study of pharmacoresistant epilepsy and the discovery of new antiepileptic drugs.

Table of Contents

Part I: Novel Approaches for the Treatment of Epilepsy

1. Inflammatory Cytokines as Targets for Epilepsy Drug Therapy

Maria-Leonor Lopez-Meraz, Jesus-Servando Medel-Matus, and Jerome Niquet

2. The Use of Anti-Inflammatory Drugs in Epilepsy

Maria Guadalupe Valle-Dorado, Laura Elena Cordova-Davalos, Daniel Perez-Perez, Rosalinda Guevara-Guzman, and Luisa Rocha

3. Carbonic Anhydrase and Epilepsy

Luciana Gavernet

4. Synaptic Vesicle Protein 2A as a Novel Pharmacological Target with Broad Potential for New Antiepileptic Drugs

Luz Adriana Pichardo-Macias, Itzel Jatziri Contreras-Garcia, Sergio R. Zamudio, Edgar Mixcoha, and Julieta G. Mendoza-Torreblanca

5. Do Cannabinoids Represent a Good Therapeutic Strategy for Epilepsy?

Cecilia Zavala-Tecuapetla and Luisa Rocha

6. Glutamate Receptors as Targets for Novel Antiepileptic Drug Therapy

Manola Cuellar-Herrera, Cesar E. Santana-Gomez, Francia Carmona-Cruz, Daruni Vazquez-Barron, Francisco Velasco, and Ana L. Velasco

7. Neurosteroid Regulation of Seizures: Role of GABAA Receptor Plasticity

Suchitra Joshi and Jaideep Kapur

8. Erythropoietin as Potential Neuroprotective and Antiepileptogenic Agent in Epilepsy and Refractory Epilepsy

Amalia Marelli, Liliana Czornyj, Luisa Rocha, and Alberto Lazarowski

9. Caloric Restriction and Dietary Treatments of Epilepsy: Mechanistic Insights for Drug Discovery

Karla G. Carvajal Aguilera and Bryan V. Phillips Farfan

10. Gene Therapy in Epilepsy

Miguel A. Lopez-Garcia, Iris A. Feria-Romero, Julia J. Segura-Uribe, David Escalante-Santiago, and Sandra Orozco-Suarez

Part II: Innovative Solutions for the Screening of New Antiepileptics Drugs and Addressing the Multi-Drug Resistance Issue Epilepsy

11. Human Brain Tissue as a Model for the Study of Epilepsy

Leonardo Lara-Valderrabano, Ivette Banuelos-Cabrera, Victor Navarrete-Modesto, and Luisa Rocha

12. The Blood-Brain Barrier and the Design of New Antiepileptic Drugs

Gabriela Rogel-Salazar and Hiram Luna-Munguia

13. Virtual Screening Applications in the Search of Novel Antiepileptic Drug Candidates

Alan Talevi and Luis E. Bruno-Blanch

14. Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Ligand-Based Approximations

Manuel Couyoupetrou, Mauricio Di Ianni, Melisa Gantner, Guido Pesce, Roxana Peroni, Alan Talevi, and Luis E. Bruno-Blanch

15. Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Structure-Based Approximations

Pablo Palestro and Luciana Gavernet

16. Nanoformulations of Antiepileptic Drugs: In Vitro and In Vivo Studies

Maria E. Ruiz and Guillermo R. Castro

Part III: Potential Contributions of Network Pharmacology and Drug Repurposing in Antiepileptic Drug Discovery

17. Side Effects of Antiepileptic Drugs

Hana Kubova

18. Network Pharmacology and Epilepsy

Alan Talevi

19. The Importance of Drug Repurposing in the Field of Antiepileptic Drug Development

Alan Talevi

Additional information

Antiepileptic Drug Discovery: Novel Approaches by Alan Talevi
Humana Press Inc.
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
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