Part I: Genetic Mechanisms of G Protein-Coupled Receptors
1. G Protein-Coupled Receptors: Research and Methods in the Post-Genomic Era
Craig W. Stevens
2. Examining the Dynamic Evolution of G Protein-Coupled Receptors
Claudia Staubert, Diana Le Duc, and Torsten Schoeneberg
3. Functional Properties of Virus-Encoded and Virus-Regulated G Protein-Coupled Receptors
Katja Spiess and Mette M. Rosenkilde
4. Discovery and Function of the Very Large G Protein-Coupled Receptor
Perrin C. White and D. Randy McMillan
5. Functional Evolution of Opioid Family G Protein-Coupled Receptors
Eyal Vardy, Craig W. Stevens, and Bryan L. Roth
6. Investigation of G Protein-Coupled Receptor Function and Regulation Using Antisense
Jonathon Mark Willets and Craig Nash
7. Signalosome Profiling Reveals Allosteric Interactions Between G Protein-Coupled Receptors
Katrin Altosaar, Darlaine Petrin, Dominic Devost, and Terence E. Hebert
Part II: Genetic Toolbox for G Protein-Coupled Receptor Discovery
8. Use of Optogenetic Approaches to Control Intracellular Signaling of G Protein-Coupled Receptors
Olivia A. Masseck, Melanie D. Mark, and Stefan Herlitze
9. Viral Infection for G Protein-Coupled Receptor Expression in Eukaryotic Cells
Antonio Porcellini, Luisa Iacovelli, and Antonio De Blasi
10. Using In Vitro Mutagenesis to Characterize Structure-Function Relationships in G Protein-Coupled Receptors
Gregory W. Sawyer and Frederick J. Ehlert
11. The CRE Luc Mouse Model for Bioimaging Ligand Activation of G Protein-Coupled Receptors
H. Gregory Polites and Kyriakos D. Economides
12. Inducing Conformational Changes in G Protein-Coupled Receptors by Domain Coupling
Hamiyet Unal and Sadashiva S. Karnik
13. Rescue of Defective G Protein-Coupled Receptor Function by Intermolecular Cooperation
Ashutosh Trehan, Kim Carol Jonas, Ilpo Huhtaniemi, Aylin Carla Hanyaloglu, and Adolfo Rivero-Muller
14. Design of Super-Arrestins for Gene Therapy of Diseases Associated with Excessive Signaling of G Protein-Coupled Receptors
Vsevolod V. Gurevich and Eugenia V. Gurevich
Part III: Genetic Aspects of G Protein-Coupled Receptors in Health and Medicine
15. Importance of G Protein-Coupled Receptor Genetics in Clinical Medicine
Ramakrishna Devaki
16. Pharmacogenomics of G Protein-Coupled Receptor Signaling and Other Pathways in Essential Hypertension
Pedro A. Jose, Van Anthony M. Villar, Matthew R. Weir, and Robin A. Felder
17. Exon Sequencing of G Protein-Coupled Receptor Genes and Perspectives for Disease Treatment
Angeliki Karamitri and Ralf Jockers
18. Gene Therapy Using G Protein-Coupled Receptors for the Treatment of Cardiovascular Disease
Dario Leosco, Grazia D. Femminella, Claudio de Lucia, and Giuseppe Rengo
19. Novel Mechanisms of G Protein-Coupled Receptor Oligomer and Ion Channel Interactions in Nociception
Ajay S. Yekkirala
20. Discovery and Characterization of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors
Marie-Isabelle Garcia, Valeria Fernandez-Vallone, and Gilbert Vassart
21. The Role of G-Protein Coupled Receptors in Adult Neurogenesis
Katie M. Collette, Van A. Doze, and Dianne M. Perez
