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Basic Clinical Radiobiology Michael C. Joiner (Department of Radiation Oncology, Wayne State University, MI, USA)

Basic Clinical Radiobiology By Michael C. Joiner (Department of Radiation Oncology, Wayne State University, MI, USA)

Summary

This textbook sets out the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology, clinical radiation physics, and radiation technology.

Basic Clinical Radiobiology Summary

Basic Clinical Radiobiology by Michael C. Joiner (Department of Radiation Oncology, Wayne State University, MI, USA)

Basic Clinical Radiobiology is a concise but comprehensive textbook setting out the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology, clinical radiation physics, and radiation technology.

Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, this fifth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer.

This new edition is highly illustrated with attractive 2-colour presentation and now includes new chapters on stem cells, tissue response and the convergence of radiotherapy, radiobiology, and physics. It will be invaluable for FRCR (clinical oncology) and equivalent candidates, SpRs (and equivalent) in radiation oncology, practicing radiation oncologists and radiotherapists, as well as radiobiologists and radiotherapy physicists.

Basic Clinical Radiobiology Reviews

"...a valuable resource for more clinically minded individuals needing to know the basics of tissue and tumor response to a variety of radiation regimens."

Robert J Griffin, PhD (University of Arkansas for Medical Sciences)

About Michael C. Joiner (Department of Radiation Oncology, Wayne State University, MI, USA)

Michael Joiner: Professor of Radiobiology, Wayne State University, USA

Albert van der Kogel: Emeritus Professor of Radiobiology, Radboud University Nijmegen Medical Centre, The Netherlands; also Department of Human Oncology, University of Wisconsin, USA

Table of Contents

Introduction: The significance of radiobiology and radiotherapy for cancer treatment. Irradiation-induced damage and the DNA damage response. Cell death after irradiation: How, when and why cells die. Quantifying cell kill and cell survival. Radiation dose-response relationships. Linear energy transfer and relative biological effectiveness. Physics of radiation therapy for the radiobiologist. Tumour growth and response to radiation. Fractionation: The linear-quadratic approach. The linear-quadratic approach in clinical practice. Modified fractionation. Time factors in normal tissue responses to irradiation. The dose-rate effect. Pathogenesis of normal tissue side effects. Stem cells in radiotherapy. Normal tissue tolerance and the effect of dose inhomogeneities. The oxygen effect and therapeutic approaches to tumour hypoxia. The tumour microenvironment and cellular hypoxia responses. Combined radiotherapy and chemotherapy. Molecular targeted agents for enhancing tumour response. Biological individualisation of radiotherapy. Molecular image guided radiotherapy. Retreatment tolerance of normal tissues. Biological response modification of normal tissue reactions: Basic principles and pitfalls. Hadron therapy: The clinical aspects. Tissue response models. Second cancers after radiotherapy.

Additional information

NGR9781444179637
9781444179637
1444179632
Basic Clinical Radiobiology by Michael C. Joiner (Department of Radiation Oncology, Wayne State University, MI, USA)
New
Hardback
Taylor & Francis Ltd
2018-08-20
350
N/A
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
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