The Blueprint by Christopher Price
The microcirculation of the gastrointestinal tract is under the control of both myogenic and metabolic regulatory systems. The myogenic mechanism contributes to basal vascular tone and the regulation of transmural pressure, while the metabolic mechanism is responsible for maintaining an appropriate balance between O2 demand and O2 delivery. In the postprandial state, hydrolytic products of food digestion elicit a hyperemia, which serves to meet the increased O2 demand of nutrient assimilation. Metabolically linked factors (e.g., tissue pO2, adenosine) are primarily responsible for this functional hyperemia. The fenestrated capillaries of the gastrointestinal mucosa are relatively permeable to small hydrolytic products of food digestion (e.g., glucose), yet restrict the transcapillary movement of larger molecules (e.g., albumin). This allows for the absorption of hydrolytic products of food digestion without compromising the oncotic pressure gradient governing transcapillary fluid movement and edema formation. The gastrointestinal microcirculation is also an important component of the mucosal defense system whose function is to prevent (and rapidly repair) inadvertent epithelial injury by potentially noxious constituents of chyme. Two pathological conditions in which the gastrointestinal circulation plays an important role are ischemia/reperfusion and chronic portal hypertension. Ischemia/reperfusion results in mucosal edema and disruption of the epithelium due, in part, to an inflammatory response (e.g., increase in capillary permeability to macromolecules and neutrophil infiltration). Chronic portal hypertension results in an increase in gastrointestinal blood flow due to an imbalance in vasodilator and vasoconstrictor influences on the microcirculation. Table of Contents: Introduction / Anatomy / Regulation of Vascular Tone and Oxygenation / Extrinsic Vasoregulation: Neural and Humoral / Postprandial Hyperemia / Transcapillary Solute Exchange / Transcapillary Fluid Exchange / Interaction of Capillary and Interstitial Forces / Gastrointestinal Circulation and Mucosal Defense / Gastrointestinal Circulation and Mucosal Pathology I: Ischemia/Reperfusion / Gastrointestinal Circulation and Mucosal Pathology I: Chronic Portal Hypertension / Summary and Conclusions / References / Author Biography
Price, Christopher: - Christopher Price is a native New Englander who has covered the Boston sports scene for the last 20-plus years, bringing insightful game stories and in-depth features to a variety of local and national media outlets. An award-winning sportswriter who has been honored by Northeastern University, New England Press Association, and the North Carolina Press Association for his work, he's served as a contributor to ESPN.com, SI.com, WEEI.com, and Baseball America, as well as The Boston Globe, The Washington Post, The Miami Herald and The Cape Cod Times. In addition, he's the author of New England Patriots: The Complete Illustrated History, as well as Baseball by the Beach and The Blueprint: How the New England Patriots Beat the System to Create the Last Great NFL Superpower. He lives outside of Boston with his wife Kate, his son Noah and their cat, Stretch.
| SKU | Unavailable |
| ISBN 13 | 9780312384852 |
| ISBN 10 | 0312384858 |
| Title | The Blueprint |
| Author | Christopher Price |
| Condition | Unavailable |
| Binding Type | Paperback |
| Publisher | St. Martin's Press |
| Year published | 2008-09-02 |
| Number of pages | 336 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
| Note | Unavailable |