Brain Defenders by David Perlmutter
'A science-based, actionable blueprint to shift the brain from decline to repair.' ― Dr David Sinclair, New York Times bestselling author of Lifespan
'This is one of the most distinct and important conversations I've had about the future of your brain...thought-provoking and, above all, hopeful.' ― Dr Rangan Chatterjee, from his podcast Feel Better, Live More.
A ground-breaking new book from the bestselling author Dr David Perlmutter that will transform our understanding and treatment of degenerative brain diseases.
In recent years microglia cells housed in the brain have been identified as playing a key role in a host of neurodegenerative diseases such as Alzheimer's, Parkinson's, Long Covid, and MS amongst others. When operating optimally, these cells support healthy brain function. However, when they go rogue, they cause inflammation in the brain, contributing to cell death and devastating neurological conditions.
Current drug treatments mostly mask symptoms rather than cure and the statistics are grim: worldwide, 55 million people suffer from Alzheimer's, 10 million people have been diagnosed with Parkinson's, and serious neurological disorders are on a rapid rise.
And the good news? By following the lifestyle protocol that Dr David Perlmutter presents in the book people can become 'architects of their cognitive destiny'. The Brain Defenders program is accessible to all and will help us start to win the war against the scourge of neurodegenerative diseases.
David Perlmutter consistently has his finger on the pulse of the newest and most important brain health research with every new book. Whether by lifestyle or future medicines, there is no doubt that therapeutically regulating our 'brain defenders,' known as microglia, is our best bet for preserving and promoting brain health as we age! * Dr. Rudolph Tanzi, Professor of Neurology, Harvard Medical School, and New York Times bestselling author of Super Brain *
Brain Defenders is an essential and timely work. Dr. Perlmutter masterfully integrates decades of neuroscience, metabolism, and clinical insight to reveal the mechanisms driving cognitive decline, and more importantly, how to defend the brain against them. As someone who studies the neuroprotective and anti-inflammatory effects of ketogenic metabolic therapy, I am deeply impressed by how clearly this book communicates the metabolic roots of brain resilience. Brain Defenders offers a powerful roadmap grounded in rigorous science and practical application. * Dominic D’Agostino, PhD, Associate Professor, Department of Molecular Pharmacology and Physiology, USF Morsani College of Medicine *
Brain Defenders is a landmark work that puts the power of prevention in your hands. Dr. Perlmutter offers a toolkit of practical steps to reprogram microglia and tackle the root causes of cognitive decline, making this a truly groundbreaking read. * Uma Naidoo, MD, nutritional psychiatrist, Harvard Medical School, and bestselling author of This Is Your Brain on Food *
Think your brain is a black box? Think again. In Brain Defenders, Dr David Perlmutter reveals how your brain's own immune cells and metabolism form a shield against neurodegeneration. This book is a must read for anyone seeking a roadmap on how to shore up your brain's resilience against diseases of aging. * William W. Li, MD, New York Times bestselling author of Eat to Beat Disease and Eat to Beat Your Diet *
Prepare for David to compellingly reframe neurodegenerative diseases not as inevitable genetic fates but as preventable outcomes of metabolic and immune deregulation. His exploration of immunometabolism and practical strategies-from diet to emerging therapies-offers a grounded, evidence-based blueprint for sustaining cognitive vitality across your lifespan. This book is an essential resource for clinicians and informed patients who want to shift from crisis response mode to proactive brain stewardship. * Ben Greenfield, author of Boundless *
Brain Defenders is a groundbreaking guide to understanding and protecting brain health for life. Dr. David Perlmutter combines cutting-edge research with actionable strategies to empower readers to optimize cognitive function and safeguard mental well-being. From the critical role of microglia and gut microbiome to innovative therapies like hyperbaric oxygen and CRISPR advancements, this book offers a comprehensive approach to defending against neurodegeneration. Packed with science-backed insights, it is an essential read for anyone seeking to enhance mental clarity, longevity, and overall brain wellness. * Mark Sisson, founder of Primal Kitchen Foods and author of The Primal Blueprint *
Brain Defenders offers a clear, accessible look at how metabolism, inflammation, and immune function influence brain health. Dr. Perlmutter explains why lifestyle and metabolic factors matter for long-term cognitive resilience-insights that are increasingly important in today's health landscape. Brain Defenders is a timely and must-read contribution to the conversation on brain health. * Christopher Palmer, MD, assistant professor of psychiatry, Harvard Medical School, and author of Brain Energy *
Brain Defenders reveals the breakthrough biology driving today's brain health crisis-and why this research is our best shot for the future of brain health. From cutting-edge science to practical daily tools, it's the perfect read for anyone invested in better brain health. * Austin Perlmutter, MD, coauthor of Brain Wash *
| SKU | Unavailable |
| ISBN 13 | 9781399753333 |
| ISBN 10 | 1399753339 |
| Title | Brain Defenders |
| Author | David Perlmutter |
| Condition | Unavailable |
| Binding Type | Paperback |
| Publisher | Yellow Kite |
| Year published | 2026-08-27 |
| Number of pages | 384 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
| Note | Unavailable |