Cell Survival and Cell Death, Second Edition by Kim Newton

Cell Survival and Cell Death, Second Edition by Kim Newton

In multicellular organisms, cell death is required for normal development, homeostasis, and the elimination of infected or injured cells. The mechanisms by which cell death occurs are genetically encoded and carefully controlled. Perturbations that enhance or suppress cell death may lead to cancer, neurodegeneration, and inflammatory diseases.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on the cell signaling that underlies the main cell death programs (apoptosis, pyroptosis, and necroptosis) and how this knowledge is driving the development of therapeutic drugs to treat some human diseases. Contributors describe in detail the molecular mechanisms of cell death signaling and the myriad players involved, including death receptor-ligand systems, BCL-2 family proteins, caspases, inflammasomes, gasdermin, MLKL, RIPK1, A20, and XIAP. They also examine the involvement of cell death programs in various pathologies and the therapeutic potential of inhibiting key pathway components.

Chapters are additionally devoted to cell death signaling mechanisms in plants and lower organisms, as well as the evolution of those mechanisms and the influence of pathogens that seek to evade them. This volume is therefore an essential reference for cell and developmental biologists, cancer biologists, and all who wish to explore recent progress in our understanding of cell death programs.

SKU	Unavailable
ISBN 13	9781621823551
ISBN 10	1621823555
Title	Cell Survival and Cell Death, Second Edition
Author	Kim Newton
Series	Perspectives Cshl
Condition	Unavailable
Binding Type	Hardback
Publisher	Cold Spring Harbor Laboratory Press,U.S.
Year published	2020-05-31
Number of pages	310
Cover note	Book picture is for illustrative purposes only, actual binding, cover or edition may vary.