Evolutionary conserved features of FG repeats that allow the formation of hydrogel-based perme-ability barriers with NPC-like properties by Hermann Broder Schmidt

Evolutionary conserved features of FG repeats that allow the formation of hydrogel-based perme-ability barriers with NPC-like properties by Hermann Broder Schmidt

Non-globular FG domains constitute the permeability barrier of nuclear pore complexes (NPCs), which control all macromolecular exchange between nucleus and cytoplasm. Whilst objects smaller than 30kDa can passively diffuse across this barrier, larger molecules need to be chaperoned by nuclear transport receptors (NTRs). However, the modus operandi and, inextricably linked, the exact physical nature of the NPC permeability barrier are still controversially discussed. Whereas so far, most studies exclusively focused on yeast or vertebrate FG domains, the ability of FG domains from different species to form selective barriers was explored here. Interestingly, all studied species contain 'cohesive' FG domains that interact with each other to form a characteristic (hydrogel) phase mimicking the permeability properties of NPCs.

SKU	Unavailable
ISBN 13	9783954044917
ISBN 10	3954044919
Title	Evolutionary conserved features of FG repeats that allow the formation of hydrogel-based perme-ability barriers with NPC-like properties
Author	Hermann Broder Schmidt
Condition	Unavailable
Binding Type	Paperback
Publisher	Cuvillier
Year published	2013-08-23
Number of pages	172
Cover note	Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
Note	Unavailable