Rethinking Cancer by Bernhard Strauss
Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence. Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been so unclear what to do with this knowledge. In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. The contributors propose a complex systems view of cancer, presenting conceptual building blocks for a new research paradigm supported by empirical evidence. The contributors first discuss the new research framework in terms of theoretical foundations and then take up the relevance of a systems approach, reviewing such topics as nonlinearity, recurrence after treatment, the cellular attractor concept, network theory, and non-coding DNA--the dark matter of our genome. They address the temporality of cancer progression, drawing on evolutionary theory and clinical experience. Finally, they cover the dominant role of the tissue microenvironment in cancer, analyzing topics including altered metabolic pathways, the disease-defining influence on metastasis, and the interconnectedness of different environmental niches across levels of organization.
Bernhard Strauss is Senior Research Associate at Cambridge University. Marta Bertolaso is Associate Professor of Philosophy of Science, Faculty of Engineering, University Campus Bio-Medico of Rome. Ingemar Ernberg leads the Ingemar Ernberg Group in the Department of Microbiology, Tumor, and Cell Biology at the Karolinska Institutet in Stockholm. Mina J. Bissell is Distinguished Scientist in the Biological Systems and Engineering Division at Lawrence Berkeley National Laboratory.
| SKU | Unavailable |
| ISBN 13 | 9780262045216 |
| ISBN 10 | 0262045214 |
| Title | Rethinking Cancer |
| Author | Bernhard Strauss |
| Series | Vienna Series In Theoretical Biology Ser |
| Condition | Unavailable |
| Binding Type | Hardback |
| Publisher | MIT Press Ltd |
| Year published | 2021-04-27 |
| Number of pages | 376 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
| Note | Unavailable |