Rune by Christopher Fowler
Alzheimer's disease invades the brain from the inside. Unlike an abcess, a metas- tasis or an infarct, the disease follows specific tracks and avoids certain cortical areas while flourishing in others. Any observer is struck by the exquisite selectiv- ity of the lesions and could, indeed, conclude that Alzheimer's disease knows neuroanatomy. However, should the term disease be used to define this disor- der? Several genes, located on at least three different chromosomes, have been implicated in the disease. The ApoE4 genotype has been shown to be an impor- tant risk factor, but dementia pugilistica also suggests that environment can be involved in at least some aspects of the disorder. These data favor the now preva- lent view that Alzheimer's disease should instead be considered as a syndrome, and probably all of the contributors to this volume are ready to endorse this point of view. If Alzheimer's syndrome is the final common pathway to several pathoge- netic mechanisms, there should be an event at one point in the course of the spe- cific etiology that triggers a somewhat stereotypic diffusion process along some neural connections. Scientists who are fascinated by the way in which the ner- vous system has morphologically encoded its function after a long phylogenetic history are also fascinated by this pathological progression of Alzheimer's syn- drome.Christopher Fowler, a London native, has spent more than thirty years writing for film, television, radio, graphic novels, and newspapers, including The London Times. He contributes a weekly column to The Independent on Sunday. Fowler has won numerous awards for his work, which includes the acclaimed Bryant & May mystery series. He has been nominated for eight national book awards in the last year. For more information, go to www.christopherfowler.co.uk.
| SKU | Unavailable |
| ISBN 13 | 9780345364739 |
| ISBN 10 | 0345364732 |
| Title | Rune |
| Author | Christopher Fowler |
| Condition | Unavailable |
| Binding Type | Hardback |
| Publisher | Ballantine Books |
| Year published | 1991-01-09 |
| Number of pages | 340 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
| Note | Unavailable |