Uroboros: The Circle of Time by Tania Henzell-Thomas

Uroboros: The Circle of Time by Tania Henzell-Thomas

t Heinz Red and Gunther Sch ag Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria The word sepsis derives from the Greek meaning decay or rottenness. Tradition- ally this term has been used to describe the process of infection accompanied by the host's systemic inflammatory response. Based on that understanding, previous clin- ical studies have been designed to include only patients with positive blood cultures 1, 2]. However, the frequent occurrence of a septic response without the demon- stration of microorganisms in the circulation has led to a new definition and under- standing of sepsis, mainly as the systemic response of the host to an often unde- tectable microbiological or non-microbiological process 3]. The general consensus is that cytokines are central to the inflammatory response, particularly in sepsis. It is now known that not only Gram-negative but also Gram- positive, viral, and fungal infections initiate the complex cascades of cytokine release. Probably the most important aspect of bacterial action is the release of toxic bacterial products. In particular endotoxin from Gram-negative bacteria (see chap- ter by Schade) and super antigens (see chapter by Neumann and Holzmann), as well as pore-forming toxins 4] from Gram-positive bacteria, induce cytokine formation. The importance of this cytokine release is evident from both diagnostic and thera- peutic (mostly experimental) studies, and the action of cytokines may be the key to our understanding of the pathophysiology of the sepsis syndrome.

SKU	Unavailable
ISBN 13	9780957138858
ISBN 10	0957138857
Title	Uroboros: The Circle of Time
Author	Tania Henzell-Thomas
Condition	Unavailable
Binding Type	Paperback
Publisher	Chickpea Press Ltd
Year published	2019-03-02
Number of pages	248
Cover note	Book picture is for illustrative purposes only, actual binding, cover or edition may vary.