Part I: Molecular Exercise Physiology
Chapter 1. The Cell
-Cellular Architecture
-Exercise and the Cell
-Conclusion
Chapter 2. Cellular Life Span
-Cell Cycle and Tissue Turnover
-Cell Death
-Effect of Exercise on Cell Proliferation and Cell Death
-Conclusion
Chapter 3. Genes, Genetic Heterogeneity, and Exercise Phenotypes
-Genes and Genome
-Gene Expression
-Regulation of Gene Expression
-Exercise and Gene Expression
-DNA Sequence Variation
-Genetics and Responsiveness to Exercise Training
-Conclusion
Chapter 4. Proteins and Exercise
-Protein Synthesis
-Protein Degradation
-Exercise and Protein Metabolism
-Conclusion
Chapter 5. Extracellular Matrix and Exercise
-Extracellular Matrices
-Composition of the Interstitial Extracellular Matrix
-Composition of Basement Membranes
-Synthesis of Collagens
-Degradation of Collagens
-ECM of Skeletal Muscle
-Muscle ECM and Physical Activity
Chapter 6. Regulation of Intracellular Ion Composition and pH
-Potassium
-Intracellular pH Regulation
-Magnesium
Chapter 7. Inter- and Intracellular Signaling
-Hormones and Receptors
-Intracellular Signal Transduction
Chapter 8. Energy Turnover and Substrate Utilization
-Skeletal Muscle Carbohydrate Metabolism During Exercise
-Recent Advances in the Regulation of Long Chain Fatty Acid Transport and Metabolism
-Molecular Basis of Lactate Transport in Skeletal Muscle
Chapter 9. Generation and Disposal of Reactive Oxygen and Nitrogen Species
-Reactive Oxygen and Nitrogen Species in Living Organisms
-Reactive Oxygen and Nitrogen Species in Exercise
-Conclusion
Chapter 10. Cellular Responses to Environmental Stress
-Hyperthermia
-Hypoxia
Part II: Exercise and the Cell
Chapter 11. Exercise and the Cardiac Myocyte
-Structure of the Cardiac Myocyte
-Contractile Cycle and Excitation-Contraction Coupling
-Adaptive Hypertrophy and Growth Signaling
-Contractile Function and Calcium Handling
Chapter 12. Exercise and Endothelium
-Endothelium Cell Function
-Effects of Physical Training on Vascular Reactivity
-Conclusion
Chapter 13. Activity-Dependent Adaptive Responses of Skeletal Muscle Fibers
-The Multiplicity of Sarcomeric Protein Isoforms
-Myofibrillar Protein Isoforms and Fiber Diversity
-Metabolic Adaptations of Muscle Fibers to Altered Functional Demands
-Fiber Type Transitions
-Signaling Pathways Related to Fiber Type Transitions
-Conclusion
Chapter 14. Exercise and the Alveolar and Bronchial Epithelial Cell
-Airways
-The Alveolar Epithelium
Chapter 15. Exercise and the Liver Cell
-Hepatic Carbohydrate Metabolism
-Hepatic Lipid Metabolism
-Conclusion
Chapter 16. Exercise and the Adipocyte
-The Adipocyte: Characteristics and Functions
-Adipocyte Receptors and Exercise
-Conclusion
Chapter 17. Erythrocytes
-Red Cell Production
-Principles of O2 Transport by the Hemoglobin Molecule
-Principles of CO2 Transport in the Blood
-Regulation of Red Cell Volume
-Red Cell Influence on Circulation and Respiration
-Erythrocyte and Radicals
-Conclusion
Chapter 18. Leukocytes
-Acute Exercise and Leukocytes
-Mechanisms of Action
-Chronic Exercise and Leukocyte Subpopulations
-Exercise and Infections
-Conclusion
Chapter 19. Exercise and the Brain
-Exercise Improves Cognitive Function in Humans and Prevents Age-Related Brain Atrophy
-Animal Models to Study the Effects of Exercise on Brain Function
-Exercise Up-Regulates Brain-Derived Neurotrophic Factor
-Gene Microarray Analysis Reveals Other Genes That Are Regulated by Exercise
-Exercise Enhancement of Learning and BDNF
-Exercise and Depression
-Definitive Role for BDNF in Human Cognition
-CNS and Peripheral Regulatory Mechanisms of Exercise Effect on BDNF
-Conclusion