This supplement provides students with access to interesting and relevant clinical and diagnostic information. It includes introductory sections about the scientific method and the applications of chemistry and cell biology to clinical work, sections about each body system that parallel the textbook organization and provide more detailed clinical information, a full-color Surface Anatomy and Cadaver Atlas, and Critical-Thinking Questions for each body system. The Applications Manual is fully cross-referenced to the textbook to promote the integration of this material into the course.