In a devestated 21st Century, Neo-Tokyo, the armed might of Earth is massed against the godlike powers of two psychic titans, the mute child Akira and the deranged youth Tetsuo. While Akira has unintentionally destroyed the city twice before, Tetsuo has ravaged the surface of the Moon for his sheer amusement, and his madness grows asohis abilities expand. Butohe is gradually losing control of the limitless energies that rage within him, mutating Tetsuo into a horror beyond imagination as all forces converge for a final confrontation.