Part I. Diagnosis, Pathophysiology, and Medical Management of Emphysema The Pathogenesis and Pathophysiology of Emphysema Neil W. Schluger and Jeanine D'Armiento Cardiopulmonary Exercise Testing in the Evaluation of the Patient with Emphysema David Balfe and Zab Mohsenifar Cardiovascular Effects of Emphysema Steven M. Scharf Radiologic Assessment of Emphysema in LVRS Candidates John H. M. Austin, Gregory D. N. Pearson, Maria C. Shiau, and Yahya M. Berkmen Medical Management of Emphysema and Chronic Obstructive Pulmonary Disease Chun K. Yip Pulmonary Rehabilitation in Severe Emphysema Matthew N. Bartels Part II. Lung Volume Reduction Surgery for Emphysema The History of Surgery for Emphysema Joseph J. DeRose, Jr. and Kenneth M. Steinglass Lung Volume Reduction Surgery: Open Technique Antonio L. Visbal, Claude Deschamps, and James P. Utz Lung Volume Reduction Surgery: Video-Assisted Thoracoscopic Approaches Joshua R. Sonett and Mark J. Krasna Anesthetic Management of the Patient Undergoing Lung Volume Reduction Surgery Ellise S. Delphin Perioperative and Nursing Care of the LVRS Patient Patricia A. Jellen and Frances Brogan Selection of Candidates for Lung Volume Reduction Surgery Byron Thomashow Clinical Results and Clinical Trials in Lung Volume Reduction Surgery Charles W. Hoopes and Mark D. Iannettoni Effect of Lung Volume Reduction Surgery on Survival in Patients with Advanced Emphysema Michael Argenziano, Lyall A. Gorenstein, and Mark E. Ginsburg Management of the Patient with Lung Cancer and Severe Emphysema Joseph J. DeRose, Jr., Michael Argenziano, and Mark E. Ginsburg Lung Transplantation and LVRS in the Treatment of Advanced Emphysema Larry L. Schulman