In 1910, Dr. John Watson travels to Egypt with his wife Juliet. Her tuberculosis has returned and her doctor recommends a stay at a sanitarium in a dry climate. But while his wife undergoes treatment, Dr. Watson bumps into an old friend - Sherlock Holmes, in disguise and on a case. An English Duke with a penchant for egyptology has disappeared, leading to enquiries from his wife and the Home Office. Sherlock Holmes has discovered that the missing duke has indeed vanished from his lavish rooms in Cairo and that he was on the trail of a previous undiscovered and unopened tomb. And that he's only the latest Egyptologist to die or disappear under odd circumstances. With the help of Howard Carter, Holmes and Watson are on the trail of something much bigger, more important, and more sinister than an errant lord.