Jane Stanford, the co-founder of Stanford University, died in Honolulu in 1905, shortly after surviving strychnine poisoning in San Francisco. The inquest testimony of the physicians who attended her death in Hawaii led to a coroner's jury verdict of murder-by strychnine poisoning. Stanford University President David Starr Jordan promptly issued a press release claiming that Mrs. Stanford had died of heart disease, a claim that he supported by challenging the skills and judgment of the Honolulu physicians and toxicologist. Jordan's diagnosis was largely accepted and promulgated in many subsequent historical accounts.

In this book, the author reviews the medical reports in detail to refute Dr. Jordan's claim and to show that Mrs. Stanford indeed died of strychnine poisoning. His research reveals that the professionals who were denounced by Dr. Jordan enjoyed honorable and distinguished careers. He concludes that Dr. Jordan went to great lengths, over a period of nearly two decades, to cover up the real circumstances of Mrs. Stanford's death.