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Cross-over Trials in Clinical Research Stephen S. Senn (Department of Statistical Science and Department of Epidemiology and Public Health University College, London, UK)

Cross-over Trials in Clinical Research By Stephen S. Senn (Department of Statistical Science and Department of Epidemiology and Public Health University College, London, UK)

Cross-over Trials in Clinical Research by Stephen S. Senn (Department of Statistical Science and Department of Epidemiology and Public Health University College, London, UK)

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Summary

This text look at cross-over trials which are experiments in which subjects, whether patients or healthy volunteers, are each given a number of treatments with the object being to study the differences between these treatments. They are used extensively in clinical research.

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Cross-over Trials in Clinical Research Summary

Cross-over Trials in Clinical Research by Stephen S. Senn (Department of Statistical Science and Department of Epidemiology and Public Health University College, London, UK)

Cross-over trials are an important class of design used in the pharmaceutical industry and medical research, and their use continues to grow. Cross-over Trials in Clinical Research, Second Edition has been fully updated to include the latest methodology used in the design and analysis of cross-over trials. It includes more background material, greater coverage of important statistical techniques, including Bayesian methods, and discussion of analysis using a number of statistical software packages.
* Comprehensive coverage of the design and analysis of cross-over trials.

* Each technique is carefully explained and the mathematics is kept to a minimum.

* Features many real and original examples, taken from the author's vast experience.

* Includes discussion of analysis using SAS, S-Plus and, GenStat, StatXact and Excel.

* Written in a style suitable for statisticians and physicians alike.
Primarily aimed at statisticians and researchers working in the pharmaceutical industry, the book will also appeal to physicians involved in clinical research and students of medical statistics.

Cross-over Trials in Clinical Research Reviews

"clearly writtenmode of presentation is very effectiveI recommend this book as a useful resource" (Journal of the American Statistical Association, December 2004)

"The book by Senn was the very first volume in Wiley's excellent series, "Statistics in Practice". Here, 10 years later, it is now the first of the books in that series to reappear in a second addition. (Technometrics, May 2004)

"...well structured and easy to read...incredibly useful..." (Applied Clinical Trials, December 2002)

"...an excellent reference source and is easily readable." (The Statistician)

"...explanation are kept as non-technical as possible, although they do not lack statistical rigour...well worth reading..." (Pharmaceutical Statistics, Vol 2, 2003)

the main additions can be seen asadding to the arguments for the authors view on carryover affects... (Clinical Trials, No.1 2004)

About Stephen S. Senn (Department of Statistical Science and Department of Epidemiology and Public Health University College, London, UK)

Stephen Senn has worked for the NHS in England, as a lecturer in Scotland and in drug development in Switzerland (with CIBA-Geigy). Until recently he was Professor of Pharmaceutical and Health Statistics at University College London but since September 2003 he has been Professor of Statistics at Glasgow University. His books, Cross-over Trials in Clinical Research (1993, 2nd edition 2002) and Statistical Issues in Drug Development (1997) are published by Wiley and his latest book, Dicing with Death (2003) by Cambridge University Press. In 2001, he was the first recipient of the George C Challis award for biostatistics of the University of Florida. He is a member of the editorial boards of Statistics in Medicine, Statistical Methods in Medical Research, Pharmaceutical Statistics and Applied Clinical Trials and is a section editor for the Wiley Statistics in Practice series.

Table of Contents

Preface to the Second Edition.

Preface to the First Edition.

1. Introduction.

2. Some Basic Considerations Concerning Estimation in Clinical Trials.

3. The AB/BA Design with Normal Data.

4. Other Outcomes and the AB/BA Design.

5. Normal Data from Designs with Three or More Treatments.

6. Other Outcomes from Designs with Three or More Treatments.

7. Some Special Designs.

8. Graphical and Tabular Presentation of Cross-over Trials.

9. Various Design Issues.

10. Mathematical Approaches to Carry-over.

References.

Author Index.

Subject Index.

Additional information

CIN0471496537G
9780471496533
0471496537
Cross-over Trials in Clinical Research by Stephen S. Senn (Department of Statistical Science and Department of Epidemiology and Public Health University College, London, UK)
Stephen S. Senn (Department of Statistical Science and Department of Epidemiology and Public Health University College, London, UK)
Statistics in Practice
Used - Good
Hardback
John Wiley & Sons Inc
2002-07-18
340
N/A
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
This is a used book - there is no escaping the fact it has been read by someone else and it will show signs of wear and previous use. Overall we expect it to be in good condition, but if you are not entirely satisfied please get in touch with us

Customer Reviews - Cross-over Trials in Clinical Research