Name: Biochemistry: Updated Edition By Trude Mckee
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Biochemistry: Updated Edition Summary

Biochemistry: Updated Edition: The Molecular Basis of Life by Trude Mckee

Biochemistry: The Molecular Basis of Life is the ideal text for students who do not specialize in biochemistry but who require a strong grasp of biochemical principles. The goal of this edition has been to enrich the coverage of chemistry while better highlighting the biological context. Once concepts and problem-solving skills have been mastered, students are prepared to tackle the complexities of science, modern life, and their chosen professions. Key features A review of basic principles Chemical and biological principles in lanace Real-world relevance The most robust problem-solving program availale Simple, clear illustrations Currency New to this edition 258 additional end-of-chapter revision questions New chemistry primer New chapter-opening vignettes New 'Biochemistry in Perspective' boxes Expanded coverage throughout In-chapter 'key concept' lists

1. Biochemistry: An IntroductionOpening Vignette: Life: It Is a Mystery!1.1 What Is Life?1.2 BiomoleculesFunctional Groups of Organic BiomoleculesMajor Classes of Small Biomolecules1.3 Is the Living Cell a Chemical Factory?Biochemical ReactionsEnergyOverview of MetabolismBiological Order1.4 Systems BiologyEmergenceRobustnessModularityBiochemistry in the Lab: An Introduction 2. Living CellsOpening Vignette: Our Bodies, Our Selves2.1 Basic ThemesWaterBiological MembranesSelf-AssemblyMolecular MachinesMacromolecular CrowdingSignal Transduction2.2 Structure of Prokaryotic CellsCell WallPlasma MembraneCytoplasmPili and Flagella2.3 Structure of Eukaryotic CellsPlasma MembraneEndoplasmic ReticulumGolgi ApparatusNucleusVesicular OrganellesMitochondriaPeroxisomesPlastidsCytoskeleton: An expanded section introduces the concept of intraflagellar transport.RibosomesNew! Biochemistry in Perspective: Primary Cilia and Human Disease: A new box describes how defects in the structural and functional properties of primary cilia contribute to human disease.Biochemistry in the Lab: Cell TechnologyAvailable Online: Biochemistry in Perspective: Organelles and Human Disease 3. Water: The Matrix of LifeOpening Vignette: Water, Water Everywhere 3.1 Molecular Structure of Water3.2 Noncovalent BondingIonic InteractionsHydrogen BondsVan der Waals Forces3.3 Thermal Properties of Water3.4 Solvent Properties of WaterHydrophillic Molecules, Cell Water Structuring, and Sol-Gel TransitionsHydrophobic Molecules and the Hydrophobic EffectAmphipathic MoleculesOsmotic Pressure3.5 Ionization of WaterAcids, Bases, and pHBuffersPhysiological BuffersNew! Biochemistry in Perspective: Cell Volume Regulation and Metabolism: A new box describes the relationship between metabolic pathways and cell volume changes triggered by osmotic imbalances.Available Online: Biochemistry in Perspective: Water, Abiotic Stress, and Compatible Solutes 4. EnergyOpening Vignette: Energy and Life's Deep Dark Secrets4.1 ThermodynamicsFirst Law of ThermodynamicsSecond Law of Thermodynamics4.2 Free EnergyStandard Free Energy ChangesCoupled ReactionsThe Hydrophobic Effect Revisited4.3 The Role of ATPBiochemistry in Perspective: Nonequilibrium Thermodynamics and the Evolution of LifeAvailable Online: Biochemistry in Perspective: The Extremophiles: Organisms That Make a Living in Hostile Environments 5. Amino Acids, Peptides, and ProteinsOpening Vignette: Spider Silk: A Biosteel Protein5.1 Amino AcidsAmino Acid ClassesBiologically Active Amino AcidsModified Amino Acids in ProteinsAmino Acid StereoisomersTitration of Amino AcidsAmino Acid Reactions5.2 Peptides5.3 ProteinsProtein StructureThe Folding Problem: An updated section describes molecular chaperone-assisted protein folding.Fibrous ProteinsGlobular Proteins: 5.4 Molecular MachinesMotor ProteinsNew! Biochemistry in Perspective: Spider Silk and Biomimetics: A new box describes the structural properties of spider silk fibers and the efforts of scientists to manufacture artificial spider silk.Biochemistry in the Lab: Protein TechnologyAvailable Online:Biochemistry in Perspective: Myosin: A Molecular MachineBiochemistry in Perspective: Protein Folding and Human DiseaseBiochemistry in Perspective: Protein PoisonsBiochemistry in the Lab: Protein Sequence Analysis: The Edman Degradation 6. EnzymesOpening Vignette: Humans and Enzymes: A Brief History6.1 Properties of Enzymes6.2 Classification of Enzymes6.3 Enzyme KineticsMichaelis-Menten KineticsLineweaver-Burk PlotsMultisubstrate ReactionsEnzyme InhibitionEnzyme Kinetics, Metabolism and Macromolecular Crowding6.4 CatalysisOrganic Reactions and the Transition StateThe Roles of Amino Acids in Enzyme CatalysisThe Role of Cofactors in Enzyme CatalysisEffects of Temperature and pH on Enzyme-Catalyzed ReactionsDetailed Mechanisms of Enzyme Catalysis6.5 Enzyme RegulationGenetic ControlCovalent ModificationAllosteric RegulationCompartmentationNew! Biochemistry in Perspective: Alcohol Dehydrogenase: A Tale of Two Organisms: A new box describes the remarkable ability of the yeast Saccaromyces cerevisiae to synthesize ethanol, and the properties of human alcohol dehydrogenases.Available Online:Biochemistry in Perspective: Quantum Tunneling and CatalysisBiochemistry in Perspective: Enzymes and Clinical Medicine 7. CarbohydratesOpening Vignette: Sweet and Bitter Tastes: The Role of Sugar Molecules7.1 MonosaccharidesMonosaccharide StereoisomersCyclic Structure of MonosaccharidesReactions of MonosaccharidesImportant MonosaccharidesMonosaccharide Derivatives7.2 Disaccharides7.3 PolysaccharidesHomoglycansHeteroglycans7.4 GlycoconjugatesProteoglycansGlycoproteins7.5 The Sugar CodeLectins: Translators of the Sugar CodeNew! Biochemistry in the Lab: Glycomics: A new box describes the major technologies used to determine the structure of complex carbohydrate molecules.Available Online:Biochemistry in Perspective: Sweet MedicineBiochemistry in Perspective: Conversion of Fischer Monosaccharide Structure onto Haworth Structure 8. Carbohydrate MetabolismOpening Vignette: Metabolism and Jet Engines8.1 GlycolysisThe reactions of the Glycolytic PathwayThe Fates of PyruvateThe Energetics of GlycolysisRegulation of Glycolysis8.2 GluconeogenesisGluconeogenesis ReactionsGluconeogenesis SubstratesGluconeogenesis Regulation8.3 The Pentose Phosphate Pathway8.4 Metabolism of Other Important SugarsFructose Metabolism8.5 Glycogen MetabolismGlycogenesisGlycogenolysisRegulation of Glycogen MetabolismNew! Biochemistry in Perspective: Saccharomyces cerevisiae and the Crabtree Effect: A new box describes the metabolic mechanism whereby yeast cells convert glucose into ethanol molecules that kill competitor microbes.New! Biochemistry in Perspective: Turbo Design Can Be Dangerous: A new box describes why turbo design pathways must be rigorously controlled.Available Online:Biochemistry in Perspective: Fermentation: An Ancient Heritage 9. Aerobic Metabolism I: The Citric Acid CycleOpening Vignette: Oxygen and Evolution: Chance and Necessity9.1 Oxidation-Reduction ReactionsRedox CoenzymesAerobic Metabolism9.2 Citric Acid CycleConversion of Pyruvate to Acetyl-CoAReactions of the Citric Acid CycleFate of Carbon Atoms in the Citric Acid CycleThe Amphibolic Citric Acid CycleCitric Acid Cycle RegulationNew! The Citric Acid Cycle and Human Disease: A new section describes why several rare human diseases have been attributed to deficits in the citric acid cycle. The Glyoxylate CycleBiochemistry in Perspective: The Evolutionary History of the Citric Acid CycleAvailable Online:Hans Krebs and the Citric Acid Cycle 10. Aerobic Metabolism II: Electron Transport and Oxidative PhosphorylationOpening Vignette: Oxygen: A Molecular Paradox10.1 Electron TransportElectron Transport and Its ComponentsNew! Electron Transport: The Fluid State Model vs. the Solid-State Model: A new section describes the structural and functional properties of the respirasome.Electron Transport Inhibitors10.2 Oxidative PhosphorylationThe Chemiosmotic TheoryATP SynthesisControl of Oxidative PhosphorylationThe Complete Oxidation of GlucoseUncoupled Electron Transport10.3 Oxygen, Cell function and Oxidative StressReactive Oxygen SpeciesAntioxidant Enzyme SystemsAntioxidant MoleculesBiochemistry in Perspective: Myocardial Infarct: Ischemia and Reperfusion: An expanded reading describes the damage caused by the reintroduction of oxygen after blood flow interruption in heart muscle.Available Online:Biochemistry in Perspective: Glucose-6-Phosphate Dehydrogenase Deficiency 11. Lipids and MembranesOpening Vignette: The Low-Fat Diet11.1 Lipid ClassesFatty AcidsThe Eicosanoids: An expanded discussion of the eicosanoids describes their biological functions and roles in human disease.TriacylglycerolsWax EstersPhospholipidsNew! Phospholipases: A new section describes the functions of phospholipases.SphingolipidsSphingolipid Storage DiseasesIsoprenoidsLipoproteins11.2 MembranesNew! Membrane Structure: A new section describes the structural and functional properties of the red blood cell membrane protein AE1.Membrane FunctionNew! Biochemistry in Perspective: Membrane Fusion and Botulism: A new box describes how botulinum toxin causes muscle paralysis by preventing membrane fusion in nerve cells. Available Online:Biochemistry in Perspective: Glucose-6-Phosphate Dehydrogenase Deficiency 12. Lipid MetabolismOpening Vignette: Abetalipoproteinemia12.1 Fatty Acids, Triacylglycerols and the Lipoprotein Pathways: An expanded discussion focuses on the distribution of triacylglycerols to the body's tissues after digestion, the triacylglycerol cycle, and glycerogenesis.Fatty Acid DegradationThe Complete Oxidation of a Fatty AcidFatty Acid Oxidation: Double Bonds and Odd ChainsFatty Acid Biosynthesis: The structural and functional properties of fatty acid synthase are updated to reflect recent research. New! A new table compares the details of fatty acid b-oxidation and synthesis.Regulation of Fatty Acid Metabolism in Mammals: An expanded discussion places fatty acid metabolism regulation in the context of AMPK control of the body's biochemical pathways.New! Lipoprotein Metabolism: The Endogenous Pathway: A new section focuses on the transport of synthesized lipid molecules from the liver to the body's tissues.12.2 Membrane Lipid MetabolismPhospholipid MetabolismSphingolipid Metabolism12.3 Isoprenoid MetabolismNew! Cholesterol Metabolism: A new section describes the effects of selected drugs on the cholesterol biosynthetic pathway.Biochemistry in Perspective: Atherosclerosis: The revised box describes how LDLs trapped in arterial walls become depleted of antioxidants and then contribute to atherosclerotic damage.Biochemistry in Perspective: Biotransformation 13. PhotosynthesisOpening Vignette: Climate Change, Renewable Energy, and Photosynthesis13.1 Chlorophyll and Chloroplasts: A revised introduction provides a more detailed overview of oxygenic photosynthesis in chloroplasts13.2 Light13.3 Light Reactions: The Z-scheme is updated to reflect recent research.Photosystem II and Water OxidationPhotosystem I and NADPH SynthesisPhotophosphorylation13.4 The Light-Independent ReactionsThe Calvin Cycle: The Calvin cycle reactions are expanded to include the ribulose-1,5- bisphosphate carboxylase mechanism.PhotorespirationAlternatives to C3 Metabolism13.5 Regulation of PhotosynthesisLight Control of PhotosynthesisControl of Ribulose-1,5-Bisphosphate CarboxylaseBiochemistry in Perspective: Photosynthesis in the DeepAvailable Online:Biochemistry in Perspective: Starch and Sucrose MetabolismBiochemistry in the Lab: Photosynthetic Studies 14. Nitrogen Metabolism I: SynthesisOpening Vignette: Nitrogen and the Gulf of Mexico Dead Zone14.1 Nitrogen FixationThe Nitrogen Fixation ReactionNitrogen Assimilation14.2 Amino Acid BiosynthesisAmino Acid Metabolism OverviewReactions of Amino GroupsSynthesis of the Amino Acids14.3 Biosynthetic Reactions Involving Amino AcidsOne-Carbon MetabolismGlutathione: A newly revised section focuses on the roles of this vitally important intracellular reducing agent.NeurotransmittersNucleotidesBiochemistry in Perspective: GasotransmittersAvailable Online:Biochemistry in Perspective: Parkinson's Disease and DopamineBiochemistry in Perspective: Heme and Chlorophyll BiosynthesisBiochemistry in Perspective: The Amine NeurotransmittersBiochemistry in Perspective: Lead Poisoning 15. Nitrogen Metabolism II: DegradationOpening Vignette: Degradative Pathways and Human Disorders15.1 Protein Turnover: A newly revised section focuses on the ubiquitin proteasomal and autophagy lysosomal systems.15.2 Amino Acid CatabolismDeaminationUrea SynthesisControl of the Urea CycleCatabolism of Amino Acid Carbon Skeletons15.3 Degradation of Selected Neurotransmitters15.4 Nucleotide DegradationPurine CatabolismPyrimidine CatabolismBiochemistry in Perspective: Disorders of Amino Acid CatabolismAvailable Online:Biochemistry in Perspective: HyperammonemiaBiochemistry in Perspective: GoutBiochemistry in Perspective: Heme Biotransformation 16. Integration of MetabolismOpening Vignette: Hypertension and Uric Acid: A Diet Connection? 16.1 Overview of Metabolism16.2 Hormones and Intercellular CommunicationPeptide Hormones: An expanded section provides a more detailed description of how insulin binding to its receptor alters intracellular processesGrowth FactorsSteroid and Thyroid Hormone Mechanisms16.3 Metabolism in the Mammalian Body: Division of Labor: New emphasis is place on glucose transport mechanisms in the body's organs.Gastrointestinal TractLiverMuscleAdipose TissueBrainKidney16.4 The Feeding-Fasting CycleThe Feeding PhaseThe Fasting PhaseFeeding BehaviorBiochemistry in Perspective: Diabetes Mellitus: An extensively revised description of diabetes explains the causes and consequences of this metabolic disease.Biochemistry in Perspective: Obesity and the Metabolic Syndrome: The box is revised to reflect recent research, including the contribution of dietary fructose to the current epidemics of obesity and metabolic syndrome.Available Online:Biochemistry in Perspective: Mammalian Hormones and the Hormone Cascade SystemBiochemistry in the Lab: Hormone Methods 17. Nucleic AcidsOpening Vignette: What Makes Us Human? 17.1 DNADNA Structure: The Nature of Mutation: A newly revised and expanded discussion describes mutation types and several classes of mutagensDNA Structure: The Genetic MaterialDNA Structure: Variations on a ThemeDNA Supercoiling: A newly enhanced description of supercoiling makes this difficult topic easier to understandChromosomes and ChromatinGenome Structure17.2 RNATransfer RNARibosomal RNAMessenger RNANoncoding RNA17.3 VirusesBacteriophage T4: A Viral LifestyleBiochemistry in the Lab: Nucleic Acid MethodsNew! Biochemistry in Perspective: Epigenetics and the Epigenome: Genetic Inheritance Beyond DNA Base Sequences: A new box provides an accessible introduction to a mechanism that alters gene expression during development. Biochemistry in Perspective: HIV: An updated box reading describes the infective mechanism of HIVAvailable Online: Biochemistry in Perspective: A Short History of DNA Research: The Early Days 18. Genetic InformationOpening Vignette: DNA and Chimeras: A Biological and Medical Mystery18.1 Genetic Information: Replication, Repair, and RecombinationDNA Replication: Expanded sections describe the functions of the prokaryotic and eukaryotic DNA polymerases.DNA Repair: An updated and expanded section describes transcription-associated, mismatch, and double-strand repair.DNA Recombination18.2 TranscriptionTranscription in ProkaryotesTranscription in Eukaryotes: The structural and functional properties of RNA pol II are updated.18.3 Gene ExpressionGene Expression in ProkaryotesNew! Gene Expression in Eukaryotes: A new section describes posttranscriptional gene silencing.Biochemistry in Perspective: GenomicsNew! Biochemistry in Perspective: Carcinogenesis: A new section outlines the roles of tumor suppressors. 19. Protein SynthesisOpening Vignette: MRSA, the Superbug19.1 The Genetic CodeCodon-Anticodon InteractionsThe Aminoacyl-tRNA Synthease Reaction19.2 Protein SynthesisProkaryotic Protein SynthesisEukaryotic Protein Synthesis: Eukaryotic translation initiation is updated. New sections describe mitochondrial posttranslational protein import and mTOR-mediated translation control.New! Biochemistry in Perspective: Trapped Ribosomes: RNA to the Rescue: A new box describes the tactics used by living organisms to release ribosomes attempting to translate truncated mRNAs without stop codons.Biochemistry in Perspective: Context-Dependent Coding RearrangementBiochemistry in the Lab: ProteomicsAvailable Online:Biochemistry in Perspective: EF-Tu: A Motor Protein

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Sku

CIN0199316708G

ISBN 13

9780199316700

ISBN 10

0199316708

Title

Biochemistry: Updated Edition: The Molecular Basis of Life by Trude Mckee

Author

Trude Mckee

Condition

Used - Good

Binding type

Hardback

Publisher

Oxford University Press Inc

Year published

20130724

Number of pages

944

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N/A

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This is a used book - there is no escaping the fact it has been read by someone else and it will show signs of wear and previous use. Overall we expect it to be in good condition, but if you are not entirely satisfied please get in touch with us

Biochemistry: Updated Edition Trude Mckee

Biochemistry: Updated Edition by Trude Mckee

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Biochemistry: Updated Edition Summary

Biochemistry: Updated Edition: The Molecular Basis of Life by Trude Mckee

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