In The New Destroyer: Guardian Angel, Remo Williams, the enforcement arm of the super secret agency CURE, has been missing for a long time. While America has been under assault inside its own borders, he has been gallivanting around the world on a variety of idiotic missions-culminating most recently in a hand-to-tentacle battle against a giant squid. But now Remo is back, as is Chiun - his mentor and trainer in the ages-old disciplines of the House of Sinanju, the historic brand name which has provided assassination services for millenia to the rulers of the world. And not a moment too soon. The situation at America's borders is falling apart - not only are job-seeking immigrants sneaking across, but also a new breed of terrorists are swarming into the country, led by a charismatic Mexican known as Santa Anna. Before long, Santa Anna is calling for an armed revolution by illegal immigrants to take over the governments of the affected border states. Armed militia volunteers now patrol the south western border states attempting to safeguard the Mexican border. The nation is on the edge of violence and Dr. Harold W. Smith, the head of CURE, decides that it is time for Remo and Chiun to do what they can to defuse the ticking bomb...before it is too late.