The Actin Cytoskeleton and the Regulation of Cell Migration by Jonathan M Lee

The Actin Cytoskeleton and the Regulation of Cell Migration by Jonathan M Lee

The mammalian cytoskeleton is an internal framework of actin, tubulin, and intermediate filament proteins. Proteins of these three classes assemble non-covalently into filamentous polymers that support the structural integrity of the relatively fragile lipid plasma membrane. In addition, cytoskeletal polymers provide the mechanical strength that hold a cell together and anchor it to its growth substrate. The cytoskeleton must also have the capacity for rapid and substantial remodeling and provide the motive and tractor force necessary to drive motility. As such, the cytoskeleton has a functional duality: sufficiently rigid to prevent plasma membrane deformation but pliable enough to allow for cytokinesis; sufficiently adhesive to allow for traction but dynamic enough to allow movement from one place to another. A major research challenge in cytoskeleton biology is to understand how cytoskeletal proteins assemble and dissemble in support of physiological processes. This chapter will focus on the role of the actin cytoskeleton in cell migration. More specifically, we will focus on the actin cytoskeleton of vertebrate cells. Table of Contents: Introduction / The Fundamentals of Actin Polymerization / Accessory Proteins Regulate Actin Polymerization and Assembly / Cellular Actin Structure / Cell Migration / Summary of Cell Migration / References / Author Biography

SKU	Unavailable
ISBN 13	9781615043880
ISBN 10	1615043888
Title	The Actin Cytoskeleton and the Regulation of Cell Migration
Author	Jonathan M Lee
Condition	Unavailable
Binding Type	Paperback
Publisher	Morgan & Claypool Publishers
Year published	2013-06-01
Number of pages	71
Cover note	Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
Note	Unavailable