Clustering in Bioinformatics and Drug Discovery by John David Maccuish Norah E Maccuish
Presents an introduction to cluster analysis and algorithms in the context of drug discovery clustering applications. This book provides an understanding of the applications in clustering large combinatorial libraries for compound acquisition, HTS results, 3D lead hopping, gene expression for toxicity studies, and protein reaction data.John trained in computer science and has been involved with data mining and statistical analysis; Norah trained as a theoretical physical chemist and has mostly worked for pharmaceutical companies on drug discoveryThey run a company that merges their fields, and it is that overlap that they describe here. They explain how cluster analysis, an exploratory data analysis tool, is used in bioinformatics and cheminformatics as they relate to drug discovery. The goal is for practitioners to be aware of the relative merits of clustering methods with the data they have at hand.
—SciTech Book News, February 2011
… In this volume, the authors present sufficient options so that the user can choose the appropriate method for their data. … Practitioners in the pharmaceutical industry need an expert guide, which the authors of this book provide, to extract the most information from their data. Those of us who learned their clustering from Anderberg, Sokal and Sneath, and Willett now have a valuable additional resource suitable for the 21st century.
—From the Foreword by John Bradshaw, Barley, Hertfordshire, UK
John D. MacCuish is the founder and president of Mesa Analytics & Computing, Inc. He has co-authored several software patents and has worked on many image processing, data mining, and statistical modeling applications, including IRS fraud detection, credit card fraud detection, and automated reasoning systems for drug discovery.
Norah E. MacCuish is the chief science officer of Mesa Analytics & Computing, Inc., where she acts as a consultant in the areas of drug design and compound acquisition and as a developer of commercial chemical information software products. She earned her Ph.D. in theoretical physical chemistry from Cornell University.
| SKU | Unavailable |
| ISBN 13 | 9781439816783 |
| ISBN 10 | 1439816786 |
| Title | Clustering in Bioinformatics and Drug Discovery |
| Author | John David Maccuish Norah E Maccuish |
| Series | Chapman And Hall Crc Computational Biology Series |
| Condition | Unavailable |
| Binding Type | Hardback |
| Publisher | CRC Press |
| Year published | 2010-11-15 |
| Number of pages | 244 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
| Note | Unavailable |