Fantastic Four Volume 5: Disassembled TPB by Mark Waid

Fantastic Four Volume 5: Disassembled TPB by Mark Waid

We are excited to bring together recent research on the molecular biology of Axenfeld-Rieger syndrome (ARS) disorders. In the following chapters we will review and provide direct evidence for the molecular basis of this group of heterogeneous disorders, which include Rieger syndrome and Rieger anomaly. While ARS patients were initially diagnosed in the early 1930s the genetic basis for ARS was unknown until the recent identification of chromo- somal loci associated with this genetic disorder. In the mid-1990s Drs. Jeffrey C. Murray and Elena V. Semina identified PITX2 through positional cloning tech- niques as a gene associated with ARS. These researchers were able to iden- tify point mutations in PITX2 that were linked with ARS patients. ARS patients presented clinically with several developmental anomalies that fur- ther provided clues about the function of the PITX2 homeobox tran- scription factor. The phenotypic variability of ARS patients indicates that PITX2 can participate with many other faaors to control normal development processes. The hallmarks of ARS developmental anomalies are eye, tooth and umbilical defects. However, abnormal pituitary, heart, and craniofacial development are also detected. Thus, ARS patients provided the first link of PITX2 involvement in the development of these organs and structures. Some of these anomalies are recapitulated in epigenetic and genetic mouse, chick, zebrafish and frog studies which will be reviewed in the following chapters.

MARK WAID is an Eisner Award-winning American comic book writer. He is well known for his eight-year run as writer of the DC Comics' title THE FLASH, as well as his scripting of the limited series KINGDOM COME and SUPERMAN: BIRTHRIGHT, and his work on Marvel Comics' CAPTAIN AMERICA. Waid also served as Editor-in-Chief, and later, Chief Creative Officer of BOOM! Studios, where he wrote titles such as IRREDEEMABLE, INCORRUPTIBLE and THE TRAVELER. He has received recent acclaim for his work on the DAREDEVIL and INDESTRUCTIBLE HULK series for Marvel in 2012-2013.

CHIP ZDARSKY is a Canadian comic book artist, journalist, illustrator and designer. He is the artist and co-creator of the IMAGE comic book SEX CRIMINALS (TIME's #1 comic and graphic novel pick of 2013), the writer of HOWARD THE DUCK for MARVEL, KAPTARA for Image Comics, and the new ongoing JUGHEAD series for Archie Comics.

ADAM HUGHES is an American comic book artist and illustrator who has provided illustration work for companies such as DC Comics, Marvel Comics, Dark Horse Comics, and Lucasfilm. He is best known to American comic book readers for his renderings of pinup-style female characters, and his cover work on titles such as Wonder Woman and Catwoman. He is known as one one of the best known and distinctive comic book cover artists.

MARGUERITE BENNETT is a writer from DC Comics, Marvel, Aftershock, BOOM! Studios, Rosy Press, and more, on projects ranging from DC's BOMBSHELLS to A-FORCE to ANGELA: QUEEN OF HEL to RED SONJA to INSEXTS.

FIONA STAPLES is a Canadian comic book artist known for her work on books such as SAGA, NORTH 40, DV8: GODS AND MONSTERS, T.H.U.N.D.E.R. AGENTS and the new ARCHIE relaunch. She is a multiple Eisner and Harvey Award-winner, and has been cited as one of the best artists working in the industry.

ERICA HENDERSON is an illustrator, comic book artist and animator best known for her work on Marvel's UNBEATABLE SQUIRREL GIRL and the new ongoing JUGHEAD series for Archie Comics.

SKU	Unavailable
ISBN 13	9780785115366
ISBN 10	0785115366
Title	Fantastic Four Volume 5: Disassembled TPB
Author	Mark Waid
Series	Fantastic Four Ser
Condition	Unavailable
Binding Type	Paperback
Publisher	Marvel Comics
Year published	2005-01-01
Number of pages	136
Cover note	Book picture is for illustrative purposes only, actual binding, cover or edition may vary.