The Fifteen-Second Secret by Larry Jones

The Fifteen-Second Secret by Larry Jones

It has been more than 25 years since the identification of the FMR1 gene and the demonstration of the causative role of CG-repeat expansion in the disease pathology of fragile X syndrome (FXS), but the underlying mechanisms involved in the expansion mutation and the resulting gene silencing still remain elusive. Our understanding of the pathways impacted by the loss of FMRP function has grown tremendously, and has opened new avenues for targeted treatments for FXS. However, the failure of recent clinical trials that were based on successful preclinical studies using the Fmr1 knockout mouse model has forced the scientific community to revisit clinical trial design and identify objective outcome measures. There has also been a renewed interest in restoring FMR1 gene expression as a possible treatment approach for FXS. This special issue of Brain Sciences highlights the progress that has been made towards understanding the disease mechanisms and how this has informed the development of treatment strategies that are being explored for FXS.

Larry Jones, a Bachelor of Divinity, has received numerous awards for his charity work, including the Humanitarian Award from the National Conference of Christians and Jews. He is the author of several nonfiction books, including How to Bend Without Breaking and Life's Interruptions--God's Opportunities, as well as the novel Black Box. He lives in Oklahoma City, Oklahoma.

SKU	Unavailable
ISBN 13	9780840733405
ISBN 10	0840733402
Title	The Fifteen-Second Secret
Author	Larry Jones
Condition	Unavailable
Publisher	Thomas Nelson Publishers
Year published	1991-07-01
Number of pages	155
Cover note	Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
Note	Unavailable