Homocysteine and Vascular Disease by K Robinson

Homocysteine and Vascular Disease by K Robinson

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Summary

Studies of afflicted individuals, when combined with investigations in experimental animals, provided the basis for a concept of methionine metabo­ lism that encompassed both transmethylation and transsulfuration.

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Homocysteine and Vascular Disease by K Robinson

This is an important and timely volume. The history of research in homocysteine metabolism can be divided into three periods. The first phase was the exploration of the individual reactions and metabolites that characterize the transmethylation and transsulfuration sequences. The former originated with his description of the biosynthesis of methylpyridine and culminated in the work of Cantoni and Axelrod. Similarly the finding that insulin contained cystine was a potent catalyst for the metabolic and nutritional studies of Rose and du Vigneaud. The description and the definition of homocystinuria, a rare inherited meta- bolic disorder, marked the beginning of the second historical period. Where previously there had been few laboratories located largely in the United States soon there were numerous research groups representing many nationalities. The more intense focus led to major advances, both in the laboratory and in the clinics. Studies of afflicted individuals, when combined with investigations in experimental animals, provided the basis for a concept of methionine metabo- lism that encompassed both transmethylation and transsulfuration. The central role of homocysteine was apparent.
`The book is therefore a great reference for an up-to-date review of any one of the many pathways involved in homocysteine metabolismThe editor should be applauded for bringing together some of the leaders in the field of homocysteine research and thus compiling a comprehensive review that should be on the shelf of any scientist working in the area of homocysteine.'
Clinical Chemistry, 47:6 (2001)
MELANI BUDIANTA is an Indonesian activist and cultural studies scholar from the University of Indonesia. TONY DAY is Visiting Fellow, National Humanities Centre, Research Triangle Park, North Carolina, and Senior Associate, Carolina Asia Center of the UNC- Chapel Hill, USA ALISON DUNDON is Australian Research Council Postdoctoral Fellow, Department of Anthropology, Faculty of Arts, Australian National University, Australia RICHARD EVES is Australian Research Council QEII Fellow, Gender Relations Centre, Australian National University, Australia KENNETH M. GEORGE is Professor of Anthropology and a specialist on Indonesia, University of Wisconsin-Madison, USA DEIRDRE MCKAY is Research Fellow, Department of Human Geography, Australian National University, Australia KIRIN NARAYAN is Professor of Anthropology and Languages and Cultures of Asia, University of Wisconsin-Madison, USA NICHOLAS TAPP is Professor of Anthropology, Research School of Pacific and Asian Studies, Australian National University, Australia CAROLINE TURNER is an Art Historian and Curator, and Deputy Director of the Humanities Research Centre, Australian National University, Australia. PNINA WERBNER is Professor of Anthropology, Keele University, UK and co-editor of the Postcolonial Encounters Series
SKU Unavailable
ISBN 13 9789048154319
ISBN 10 9048154316
Title Homocysteine and Vascular Disease
Author K Robinson
Series Developments In Cardiovascular Medicine
Condition Unavailable
Binding Type Paperback
Publisher Springer
Year published 2010-12-04
Number of pages 448
Cover note Book picture is for illustrative purposes only, actual binding, cover or edition may vary.