Ion Channels: A Laboratory Manual
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Ion Channels: A Laboratory Manual by Paul J Kammermeier
The propagation of signals through the nervous system depends on rapid changes in electric potential across cell membranes. These changes are mediated by ion channelsmacromolecular pores that facilitate the passage of specific ions (e.g., K+ or Na+) through cell membranes in response to various signals. Defects in ion channels can lead to diseases such as epilepsy. This laboratory manual provides state-of-the-art techniques for investigating ion channel properties and activity, particularly in the nervous system. Contributors present electrophysiological methods to examine single-channel activity in cultured cells, to study synaptic plasticity and circuit dynamics in brain slice preparations, and to perform whole-cell recordings in awakeand even freely movinganimals. The use of optogenetic tools to study synapses or small networks in organotypic slice cultures is also covered. Many of the experimental setups described can be adapted for other ion channels, cell types, or systems. The manual includes background on the structure, function, and regulation of different voltage- and ligand-gated ion channels. Therefore, it is a useful resource for all cell biologists and neuroscientists seeking to further understand the complex roles of ion channels in normal physiology and disease.| SKU | Unavailable |
| ISBN 13 | 9781621821205 |
| ISBN 10 | 162182120X |
| Title | Ion Channels: A Laboratory Manual |
| Author | Paul J Kammermeier |
| Condition | Unavailable |
| Binding Type | Hardback |
| Publisher | Cold Spring Harbor Laboratory Press,U.S. |
| Year published | 2017-04-30 |
| Number of pages | 200 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
| Note | Unavailable |