Metallocofactors that Activate Small Molecules by Markus W Ribbe

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Summary

This volume highlights recent progress on the fundamental chemistry and mechanistic understanding of metallocofactors, with an emphasis on the major development in these areas from the perspective of bioinorganic chemistry.

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Metallocofactors that Activate Small Molecules by Markus W Ribbe

Chapter 1. Looking at Nitrogenase: Insights from Modern Structural Approaches.- Chapter 2. Current Understanding of the Biosynthesis of the Unique Nitrogenase Cofactor Core.- Chapter 3. Recent Advances in the Chemical Synthesis of Nitrogenase Model Clusters.- Chapter 4. The Catalytic Mechanisms of the Molybdenum and Tungsten Enzymes.- Chapter 5. The Role of the Pyranopterin Dithiolene Component of Moco in Molybdoenzyme Catalysis.- Chapter 6. Mechanism of Ni, Fe-Containing Carbon Monoxide Dehydrogenases.
The focus of Dr. Ribbe’s research is the assembly and mechanism of nitrogenase, one of the most complex metalloenzymes known to date. Nitrogenase can be appreciated from the perspective of the useful agricultural and industrial products it generates, namely, ammonia, hydrogen and hydrocarbons. Since the beginning of his independent career, Dr. Ribbe has focused his efforts on investigating the biosynthesis of the Mo-nitrogenase from Azotobacter vinelandii and, in particular, the unique metal centers of its MoFe protein component: FeMoco and P-cluster. Results of these studies have firmly established nitrogenase MoFe protein as a model system that could be used to deduce the general mechanism of metal cluster assembly and develop successful strategies for synthesizing bio-inspired catalysts for industrial usage. Recently, Dr. Ribbe expanded his research to the investigation of the structure and function of the “alternative” V-nitrogenase from Azotobacter vinelandii. His discovery that V-nitrogenase can convert CO to hydrocarbons provides a potential blueprint for developing cost-efficient processes for industrial production of biofuels in the future.
SKU Unavailable
ISBN 13 9783030258993
ISBN 10 3030258998
Title Metallocofactors that Activate Small Molecules
Author Markus W Ribbe
Series Structure And Bonding
Condition Unavailable
Binding Type Paperback
Publisher Springer Nature Switzerland AG
Year published 2020-09-25
Number of pages 169
Cover note Book picture is for illustrative purposes only, actual binding, cover or edition may vary.