Nucleic Acids in Chemistry and Biology by Martin Egli

Nucleic Acids in Chemistry and Biology by Martin Egli

The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.

..clear and direct style that explains complex ideas in a straightforward manner. The book does a great job of communicating the excitement of research on nucleic acids. My search for a textbook for next year's nucleic acids course appears to be over! Jennifer A. Doudna -- ACS Chemical Biology, Vol.2, No.4, 20 April 2007 ACS Chemical Biology An excellent overview of the chemistry and biology of nucleic acids, at a level that is suitable for use in university teaching, but with enough detail to be useful as a reference source for chemists, biochemists and biologists involved in current research of nucleic acids. -- Chemistry World, June 2007, p62 (Richard Bowater) Chemistry World

Mike Blackburn has been active in chemical biology research for over 50 years, beginning with chemical synthesis of a substrate analogue for ribosomal peptide synthesis (J. Mol. Biol., 1965, 13, 617-628). He studied enzyme mechanisms with W. P. Jencks (Brandeis University, 1966-7) and launched into the use of stable analogues of phosphate esters and anhydrides for studies on nucleotides and glycolysis intermediates from the late ‘70s. This has culminated in the current use of metal fluorides to generate transition state analogues for phosphoryl transfer reactions by kinases, mutases, and isomerases. He has authored some 300 research papers, several patents, one book (“Nucleic Acids in Chemistry and Biology, 3rd Edition, RSC 2005), and is a co-author for more than 70 structures in the Protein Data Bank.

SKU	Unavailable
ISBN 13	9780854046546
ISBN 10	0854046542
Title	Nucleic Acids in Chemistry and Biology
Author	Martin Egli
Condition	Unavailable
Binding Type	Hardback
Publisher	Royal Society of Chemistry
Year published	2006-11-03
Number of pages	503
Cover note	Book picture is for illustrative purposes only, actual binding, cover or edition may vary.