Oligonucleotide Synthesis
Oligonucleotide Synthesis
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Summary
Among the protocol highlights are a novel two-step process that yields a high purity, less costly, DNA, the synthesis of phosphorothioates using new sulfur transfer agents, the synthesis of LNA, peptide conjugation methods to improve cellular delivery and cell-specific targeting, and triple helix formation.
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Oligonucleotide Synthesis by Piet Herdewijn
A collection of powerful new techniques for oligonucleotide synthesis and for the use of modified oligonucleotides in biotechnology. Among the protocol highlights are a novel two-step process that yields a high purity, less costly, DNA, the synthesis of phosphorothioates using new sulfur transfer agents, the synthesis of LNA, peptide conjugation methods to improve cellular delivery and cell-specific targeting, and triple helix formation. The applications include using molecular beacons to monitor the PCR amplification process, nuclease footprinting to study the sequence-selective binding of small molecules of DNA, nucleic acid libraries, and the use of small interference RNA (siRNA) as an inhibitor of gene expression.
Piet Herdewijn is full professor of Medicinal Chemistry at the University of Leuven and director of the laboratory of medicinal chemistry at the Rega Institute for Medical Research (Belgium). He holds a Ph.D. from the same institution, having worked as a post-doctoral researcher and assistant professor at the universities of Konstanz (Germany) and Ghent (Belgium) in between. He is a member of the Belgian Academy of Medicine, representing Chemistry, and a founding member of the International Society of Nucleosides, Nucleotides, and Nucleic Acids. Apart from having close to 500 contributions to scientific journals and books to his credit, he is an editor of the Current Protocols in Nucleic Acid Chemistry, also published by Wiley.
| SKU | Unavailable |
| ISBN 13 | 9781588292339 |
| ISBN 10 | 1588292339 |
| Title | Oligonucleotide Synthesis |
| Author | Piet Herdewijn |
| Series | Methods In Molecular Biology |
| Condition | Unavailable |
| Publisher | Humana Press Inc. |
| Year published | 2004-09-01 |
| Number of pages | 436 |
| Cover note | Book picture is for illustrative purposes only, actual binding, cover or edition may vary. |
| Note | Unavailable |