Platelets and Their Factors by Franz Von Bruchhausen

Platelets and Their Factors by Franz Von Bruchhausen

Platelets playa fundamental, life-saving role in hemostasis and blood clotting at sites of vascular injury. Unwanted platelet activation and arterial thombus formation are, however, implicated in the onset of myocardial infarction, stroke, and other cardiovascular diseases. Acceptance that platelets play a major role in the pathogenesis of atherosclerosis including coronary heart disease has revolutionized the pharmacological treatment of cardiovascular diseases, and aspirin is now an essential antiplatelet drug and the golden standard for future developments. Yet the search for better and perhaps safer antiplatelet drugs is one of the most active areas of investigation in both basic and clinical research. Platelets, especially human platelets, have also emerged as one of the major models for the study of inter- and intracellular signal transduction pathways. Many biochemists, cell biologists, pharmacologists, pathologists, hematologists, and cardiologists find platelets useful for studying processes such as adhesion, inside-out and outside-in signalling through the plasma membrane, channels, calcium homeostasis, protein kinases, the network of intracellular signal transduction cascades, and the release of vasoactive substances. The aim of the editors has been to compile chapters summarizing the current state-of-the-art information on the biochemistry, cell biology, pharmacology, and physiologic and pathophysiologic roles of human platelets. We hope that this volume represents the major aspects of current platelet research although it is perhaps inevitable that certain areas are covered less thoroughly than others. We would like to acknowledge the excellent help and support of the Springer-Verlag staff, in particular that of Ms. Doris Walker.

Ulrich Walter, born in Iserlohn, Germany, received his PhD in the field of solid state physics from the University of Cologne. After two post-doc positions at the Argonne National Laboratory, Chicago, Illinois, and the University of California at Berkley, California, he joined the German astronaut team and flew in 1993 on board the space shuttle Columbia on the STS-55 (Spacelab D-2) mission. From 1998 to 2003, he held various corporate positions at the IBM Research Center, Germany, and in 2003 accepted a professorship at the Institute of Astronautics, Technische Universit't M?nchen, Germany. Professor Walter became known to a wider audience as presenter of MaxQ, a popular science show on German television, and is author of a number of popular science books on spaceflight and research.
Currently, the main focus of his scientific work is on satellite technology.

SKU	Unavailable
ISBN 13	9783642644887
ISBN 10	3642644880
Title	Platelets and Their Factors
Author	Franz Von Bruchhausen
Series	Handbook Of Experimental Pharmacology
Condition	Unavailable
Binding Type	Paperback
Publisher	Springer
Year published	2011-09-30
Number of pages	753
Cover note	Book picture is for illustrative purposes only, actual binding, cover or edition may vary.