Regulation of Aldosterone Biosynthesis by Jrg Mller

Regulation of Aldosterone Biosynthesis by Jrg Mller

Sixteen years is a long time, not only in human life but also in the rapid history of contemporary endocrinology. Since the publication of the first edition of this monograph, numerous new lines of research and discoveries have greatly contrib- uted to our knowledge of the physiological and pathological regulation of aldos- terone biosynthesis in man and animals. The first reports about a sensitive ra- dioimmunoassay for plasma aldosterone and about a preparation of dispersed zona glomerulosa cells were published in 1970 (Mayes et al. 1970; Haning et al. 1970). These two developments alone turned out to have a tremendous impact on research in aldosterone physiology (for reviews see Coghlan et al. 1979b; J. F. Tait et al. 1980b). In 1971, atrial natriuretic peptides, somatostatin, and the precursor molecule of ACTH had not yet been discovered. Angiotensin antagonists and con- verting-enzyme inhibitors were not yet available. The clinical syndrome of hypo- reninemic hypo aldosteronism was unknown. The possible roles of prostaglandins and dopamine in the control of aldosterone pwduction had not been considered. Cyclic AMP was then the only substance with a clearly established second-mes- senger function.

SKU	Unavailable
ISBN 13	9783642831225
ISBN 10	3642831222
Title	Regulation of Aldosterone Biosynthesis
Author	Jrg Mller
Series	Monographs On Endocrinology
Condition	Unavailable
Binding Type	Paperback
Publisher	Springer
Year published	2011-12-08
Number of pages	364
Cover note	Book picture is for illustrative purposes only, actual binding, cover or edition may vary.