The Reoviridae by Wolfgang K Joklik

The Reoviridae by Wolfgang K Joklik

It is now just 20 years since Gomatos and his co-workers at the Rocke- feller University showed that the nucleic acid in reovirus particles is double-stranded RNA (dsRNA). This discovery created great excitement, for dsRNA was at that time under intense investigation as the replicative form of viral genomes consisting of single-stranded RNA. An equally interesting and important finding followed soon after: it was found that the reovirus genome consists, not of a single nucleic acid molecule, but of 10 discrete segments, each with its specific sequence content and each transcribed into its own messenger RNA. It is clear now that these segments are genes. Not surprisingly, the availability of a viral genome 10 unlinked genes has permitted some unique lines of in- consisting of vestigation in molecular biology. Mammalian and avian reoviruses proved to be but the first of several viruses recognized as sharing Similarity in size and morphology and ge- nomes consisting of 10, I, or 12 separate genes. These viruses are dis- tributed throughout living organisms; among the natural hosts of mem- bers of this virus family are vertebrates, Insects, and plants. Members of the Reoviridae family differ widely in the virulence that they exhibit toward their hosts . . For example, the first discovered mam- malian reovirus literally is, as the name signifies, a respiratory enteric orphan virus, that is, a virus unassociated with disease.

SKU	Unavailable
ISBN 13	9780306412332
ISBN 10	0306412330
Title	The Reoviridae
Author	Wolfgang K Joklik
Series	The Viruses
Condition	Unavailable
Binding Type	Hardback
Publisher	Springer
Year published	1983-08-31
Number of pages	571
Cover note	Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
Note	Unavailable