Sally Mann: Immediate Family by Sally Mann

Sally Mann: Immediate Family by Sally Mann

This book describes genomic uracil in evolution, as a DNA constituent in adaptive and innate immune responses and as a mutagenic lesion causing cancer. Genomic uracil is as old as life and may have been a component in self-replicating molecules in the prebiotic era. The first living cells probably contained uracil in DNA, later to be replaced by thymine. The pioneering work of Nobel Laureate, Tomas Lindahl on spontaneous deamination of DNA cytosine to uracil was followed by his discovery of uracil-DNA glycosylase, which initiates repair of genomic uracil in base excision repair (BER). Uracil-DNA glycosylases are found in all forms of life and in DNA viruses, having roles in DNA repair, replication and epigenetics. The surprising discovery of enzymatic DNA cytosine deamination by the AID/APOBEC deaminases subsequently has implicated genomic uracil in the development of human cancer. The aim of the book is to contribute a reference text for graduate students, molecular biologists, immunologists and cancer biologists. Genomic uracil has become a hot research topic of wide interest after the Nobel Prize in Chemistry 2015 was awarded for DNA repair (Paul Modrich, Aziz Sancar and Tomas Lindahl). Furthermore, genomic uracil has received wide interest among both immunologists and cancer biologists due to its unexpected and fundamental role in adaptive immunity. Genomic uracil, thus, is highly relevant to researchers in different areas of research, but to our knowledge there is no published text that treats genomic uracil in an interdisciplinary way. The authors of this book have in the last three decades worked on genomic uracil and its processing and are among the most highly cited authors in the field.

Sally Mann has received various honors, including three fellowships from the National Endowment for the Arts and a Guggenheim fellowship. Her images have been displayed abroad and are part of the permanent collections of New York's Museum of Modern Art, Metropolitan Museum of Art, and Whitney Museum of American Art.

SKU	Unavailable
ISBN 13	9780893815233
ISBN 10	0893815233
Title	Sally Mann: Immediate Family
Author	Sally Mann
Condition	Unavailable
Binding Type	Paperback
Publisher	Aperture
Year published	2005-06-15
Number of pages	88
Cover note	Book picture is for illustrative purposes only, actual binding, cover or edition may vary.