Toll and Toll-Like Receptors: by Tina Rich

Toll and Toll-Like Receptors: by Tina Rich

Toll Receptors and the Renaissance of Innate Immunity Elizabeth H. Bassett and Tina Rich Overview n the last few pages of Immunology: The Science of Self-Nonself Discrimination Jan Klein ponders on what he would study if he were to start over in the lab. Dismissing the I antibody, MHC, the T-cell and parasitology, he considers instead the phylogeny of immune reactions, particularly in ancient phyla. As for a favored cell he chooses the macrophage. Describ- ing it as a MddchenfUr alles, (all purpose kitchen maid) Klein believed that this immunocyte still had secrets to reveal. Toll-Like Receptor (TLR) biology would prove to be one of these secrets. Analyses of the evolution of these receptors (Tolls and TLRs) have also helped us to rethink immune system phylogeny. In the first part of this chapter the history of the discovery of Toll and TLR biology is described. The evolution of the TLR genes and theories of immune function are covered in later sections. The remainder of this book presents work from nine groups active in the field. In the first chapter, The Function of Toll-Like Receptors, Zlatko Dembic sets the stage by introducing us to many of the components of the immune system and their relationships vis a vis Toll receptors. Zlatko finishes his chapter with a discussion about current immune system models and contributes his own 'integrity model'. Work from the laboratory of Nicholas Gay follows this in Structures and Motifs Involved in Toll Signaling.

SKU	Unavailable
ISBN 13	9780306482373
ISBN 10	0306482371
Title	Toll and Toll-Like Receptors:
Author	Tina Rich
Series	Molecular Biology Intelligence Unit
Condition	Unavailable
Binding Type	Hardback
Publisher	Springer
Year published	2005-01-07
Number of pages	218
Cover note	Book picture is for illustrative purposes only, actual binding, cover or edition may vary.