In the wake of the apocalyptic events in Preacher: War in the Sun, the Reverend Jesse Custer's quest to find an absentee God takes an unexpected detour, one which leads down a backwater road to the godforsaken town of Salvation! Separated from gun-toting girlfriend Tulip and Irish vampire Cassidy, Custer's looking to lose himself for a while, take stock of a life that has been torn apart. But there's no rest for the good or the wicked in Salvation, a small town with a lot of very big secrets, as Custer soon discovers.