This volume presents detailed information on the unique pharmacological and clinical properties of a recently introduced antipsychotic drug, olanzapine. Chapters examine the molecular pharmacology and neurochemical actions of olanzapine, describe its behavioral and electrophysiological effects in animal models, and relate these preclinical findings to the drug's clinical profile. The book presents extensive clinical studies of olanzapine in the treatment of schizophrenia and other psychiatric conditions, such as cognitive symptoms, mood symptoms, and hostility and aggression. These studies suggest that olanzapine has a broader spectrum of efficacy than conventional antipsychotics and a lower incidence of extrapyramidal symptoms and other adverse effects