This laboratory textbook for students of organic chemistry is designed to utilize standard-scale (macroscale) glassware and equipment but with smaller amounts of chemicals and reagents. It features a number of traditional organic reactions and syntheses, along with the isolation of natural products and experiments with a biological or health sciences focus. The organization of the text is based on essays and topics of current interest, and the book contains a comprehensive treatment of laboratory techniques including both small-scale and some microscale methods.